MCP-1 and soluble TWEAK levels are independently associated with coronary artery disease severity in patients with chronic kidney disease

Figures & data

Table 1. Demographic and clinical characteristics of the entire study population.

eGFR mL/dk/1.73 m^2	60–89	30–59	p-Value
Age (years)	64.82(41–78)	68.38 (49–82)	0.08
Sex (M/F)	44/7	37/2	0.65
Body mass index (kg/m^2)	29.35	26.47	0.54
History of CVD	3	4	0.66
CKD etiology
Diabetes mellitus	19	20	0.72
Hypertension	23	8	0.021
Glomerulonephritis	6	9	0.15
Unknown	3	2	0.53
Currently smoking	16	4	0.017

Figure 1. Gensini scoring system.

Table 2. Biochemical evaluation of the study population according to CKD stages.

	All patients	CKD stage 2	CKD stage 3	p-Value
eGFR (mL/min)	64.18 ± 16.5	71.9 ± 8.86	50.11 ± 7	<0.01
SBP (mmHg)	133.76 ± 5.1	134.21 ± 5.13	133.84 ± 4.79	0.857
DBP	84.79 ± 6.41	86.07 ± 6.58	83.2 ± 5.9	0.31
Albumin (g/dL)	4.12 ± 0.42	3.9 ± 0.72	4.2 ± 0.54	0.43
Total cholesterol (mg/dL)	188.38 ± 48.88	193.68 ± 50.26	178.05 ± 45.56	0.111
Triglyceride (mg/dL)	157.8 ± 78.14	171.29 ± 90.05	135.32 ± 55.71	0.29
Low denstiy lipoprotein (mg/dL)	116.29 ± 43.54	118.41 ± 45.01	113.23 ± 41.81	0.597
High density lipoprotein (mg/dL)	40.03 ± 11.27	41.64 ± 12.4	37.6 ± 8.8	0.112
Calcium (mg/dL)	8.52 ± 0.63	9.09 ± 0.43	8.73 ± 0.32	0.09
Phosphate (mg/dL)	5.35 ± 1.82	4.64 ± 0.83	4.84 ± 0.69	0.102
Hemoglobin (g/dL)	14.09 ± 1.75	14.55 ± 1.73	13.6 ± 1.7	<0.01
iPTH (pg/mL)	132 ± 76	72 ± 28	162 ± 53	0.086
CRP (mg/L)	6.25 ± 11.8	3.8 ± 4.5	7.99 ± 11.38	0.062
MCP-1 (pg/mL)	67.41 ± 28.11	62.56 ± 31.17	72.9 ± 22.3	0.107
sTWEAK (pg/mL)	439.29 ± 223.18	453.72 ± 240.19	435.71 ± 215.39	0.542
Gensini score	46.14 ± 35.4	41.94 ± 36.8	53.75 ± 32.4	0.047

Notes: eGFR: estimated glomerular filtration rate, SBP: systolic blood pressure, DBP: diastolic blood pressure, iPTH: intact parathyroid hormone, CRP: c-reactive protein, sTWEAK: soluble TNF-like weak inducer of apoptosis, MCP-1: monocyte chemoattractant protein-1.

Figure 2. Correlation analysis of sTWEAK and Gensini scores.

Figure 3. Correlation analysis of MCP-1 and Gensini scores.

Table 3. Demographic and laboratory values of the low- and high-Gensini groups.

	Gensini group
	Group 1	Group 2	p-Value
Age (years)	65.02 ± 9.42	66.06 ± 7.91	0.557
BMI (kg/m^2)	28.72 ± 3.26	28.21 ± 2.60	0.398
Systolic BP	133.27 ± 5.82	134.27 ± 4.25	0.335
Diastolic BP	85.61 ± 6.01	83.96 ± 6.76	0.206
eGFR	67.97 ± 17.28	60.33 ± 14.87	0.022
Hemoglobin	13.92 ± 1.86	14.28 ± 1.62	0.303
HsCRP	7.26 ± 12.95	5.22 ± 7.49	0.345
Total cholesterol	195.52 ± 42.88	181.09 ± 47.27	0.119
Triglyceride	162.97 ± 75.52	152.55 ± 70.01	0.483
HDL cholesterol	40.84 ± 9.89	39.21 ± 11.10	0.449
LDL cholesterol	121.99 ± 40.25	110.47 ± 39.82	0.16
VLDL cholesterol	32.62 ± 15.06	30.57 ± 14.03	0.49
sTWEAK	322.44 ± 139.30	558.59 ± 230.55	<0.01
MCP-1	55.80 ± 27.56	79.21 ± 23.59	<0.01

Notes: Values are shown as mean ± standard deviation.

BMI: body mass index, BP: Blood pressure, eGFR: estimated glomerular filtration rate, HDL: high density lipoprotein, LDL: low density lipoprotein, VLDL: very low density lipoprotein, sTWEAK: soluble TWEAK, MCP-1: monocyte chemoattractant protein-1.