Protective effect of pomegranate seed oil against cisplatin-induced nephrotoxicity in rat

Figures & data

Table 1. Initial and the final body weights in control group (group 1), cisplatin treated (group II) and PSO pre-treated rats (group III, IV).

Groups	Initial body weight	Final body weight
Control -	210.67 ± 4.31	211.33 ± 4.06
Cisplatin (8 mg/kg)	207.83 ± 3.93	169 ± 3.05***
PSO (0.4 mL/kg) + Cisplatin	203.50 ± 5.09	171.67 ± 4.90***
PSO (0.8 mL/kg) + Cisplatin	206.16 ± 4.90	184.50 ± 6.60**

Notes: Data were presented as the mean ± SEM (n = 8).

**p < 0.01; ***p < 0.001 compared to the control group.

Figure 1. Photomicrographs of histopathological alterations in renal tissues in response to cisplatin and PSO + cisplatin (H&E staining). Rat kidney sections from the control group showing normal histology (A, X100). Cisplatin-treated rat kidney showing tubular cell necrosis (B), hyaline casts and vascular congestion (C, X400). The arrows indicate tubular necrosis and hyaline casts. PSO + cisplatin-treated rats showed dramatic improvement in the histologic appearance. Minimal tubular necrosis was observed in group III and IV (D, X400).

Figure 2. Effect of pomegranate seed oil (0.4 and 0.8 mL/kg, i.p.) 1 h before injection of cisplatin (8 mg/kg) on concentration of urinary glucose (A), urinary protein (B), serum creatinine (C), serum urea (D), total thiol content (E) and renal MDA (F). Notes: Data were expressed as mean ± SEM (n = 8). *p < 0.05; ***p < 0.001 compared to cisplatin-treated group.