Effects of melatonin on diclofenac sodium treated rat kidney: a stereological and histopathological study

Figures & data

Table 1. Morphometrical evaluations in the control and experimental groups with their ±SEM.

Estimation	Cont	PS	DS	DS + MEL
Total volume of proximal tubules (mm^3)	1203 ± 217*	909 ± 139	1539 ± 528	2158 ± 241¥
Total volume of distal tubules (mm^3)	1792 ± 235*	1543 ± 281	1915 ± 586	2830 ± 577¥
Mean volume of glomerulus (µm^3)	162 ± 14*	158 ± 23	117 ± 19	156 ± 16¥
Mean numerical density of glomeruli (gL/mm^3)	178 ± 30*	169 ± 18	156 ± 37	161 ± 22
Total number of the glomeruli (mm^3)	416,229 ± 1200*	381,992 ± 5400	279,268 ± 900	398,098 ± 1300¥

Note: *, ¥ show significant differences between the CONT/PS and DS, also between the DS and DS + MEL groups at p < 0.05 level.

Figure 1. Images obtained from the kidney of the DS (D, E, F), Cont (A), PS (B) and DS + MEL (C) groups. Notes: Tubular necrosis (nt), sclerosis (sg), dilated glomerular capillaries (arrowheads), many mononuclear cells (in circled area) and segmental necrosis (*) of the glomeruli were detected in kidney samples of the DS group.

Figure 2. Images obtained from the kidney of the Cont (A), PS (B), DS (C) and DS + MEL (D) groups. Note: More collagen contained interstitial tissue areas were seen in kidney samples of DS group (C and D).