Association of ambulatory arterial stiffness index with sEPCR in newly diagnosed hypertensive patients

Figures & data

Table 1. Baseline characteristics and ambulatory blood pressure monitoring characteristics for the two groups.

	Group 1 (n = 263)	Group 2 (n = 55)	p-value
Age (years)	47.1 ± 6.8	46.8 ± 7.1	0.812
Male, n (%)	110 (41.8)	22 (40.0)	0.307
BMI (kg/m^2)	30.1 ± 2.7	24.6 ± 3.5	<0.01
Current smokers, n (%)	55 (20.9)	12 (21.8)	0.496
FBG (mg/dL)	91.6 ± 5.5	88.5 ± 4.9	0.612
TC (mg/dL)	213.5 ± 34.7	212.9 ± 40.2	0.769
HDL-C (mg/dL)	36.8 ± 6.5	39.7 ± 5.9	0.095
TG (mg/dL)	195.8 ± 79.6	194.7 ± 81.2	0.378
LDL-C (mg/dL)	136.8 ± 32.5	135.7 ± 36.5	0.428
CRP (mg/L)	7.3 ± 1.9	3.1 ± 1.7	0.028
UA (mg/dL)	7.1 ± 1.3	6.8 ± 1.2	0.601
eGFR (mL/min/1.73 m^2)	102.7 ± 5.2	103.1 ± 6.8	0.514
sEPCR (ng/mL)	250.66 ± 68.75	47.60 ± 21.93	<0.001
24h-SBP (mmHg)	138 ± 9	121 ± 6	<0.001
24h-DBP (mmHg)	87 ± 8	72 ± 5	<0.001
24h-MAP (mmHg)	104 ± 9	89 ± 5	<0.001
24h-PP (mmHg)	50 ± 7	49 ± 4	0.831
24h-HR (beats/min)	74 ± 6	75 ± 8	0.852
AASI	0.462 ± 0.110	0.257 ± 0.040	<0.001

Notes: Group 1: essential hypertensive patients, Group 2: normotensive controls. All values are presented as mean ± standard deviation.

BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein; LDL-C, low-density lipoprotein; CRP, C-reaction protein; sEPCR, soluble endothelial protein C receptor; MAP, mean arterial pressure; PP, pulse pressure; HR, heart rate; AASI, ambulatory arterial stiffness index.

Figure 1. sEPCR is positively associated with AASI.

Table 2. Univariate and multivariate regression analyses demonstrating factors showing correlation with ambulatory arterial stiffness index.

	Univariate		Multivariate
	r	p-value	Beta (standardized coefficients)	p-value
Age (years)	0.212	<0.001	0.061	0.483
Gender (male)	0.108	0.35
BMI (kg/m^2)	0.412	<0.001	0.102	0.239
FBG (mg/dL)	0.147	0.21
TC (mg/dL)	0.122	0.29
HDL-C (mg/dL)	−0.293	<0.001	−0.197	0.026
TG (mg/dL)	0.056	0.72
LDL-C (mg/dL)	0.102	0.41
CRP (mg/L)	0.151	0.18
UA (mg/dL)	0.097	0.56
eGFR (mL/min/1.73 m^2)	0.082	0.61
sEPCR (ng/mL)	0.894	<0.001	0.769	<0.001
24h-SBP (mmHg)	0.153	0.12
24h-DBP (mmHg)	0.075	0.66
24h-MAP (mmHg)	0.100	0.43
24h-PP (mmHg)	0.350	<0.001	0.115	0.165
24h-HR (beats/min)	0.176	0.001	0.045	0.673

Note: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; FPG, fasting plasma glucose; UA, uric acid; TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein; LDL-C, low-density lipoprotein; CRP, C-reaction protein; sEPCR, soluble endothelial protein C receptor; MAP, mean arterial pressure; PP, pulse pressure; HR, heart rate; AASI, ambulatory arterial stiffness index.