Effects of intradialytic exercise on systemic cytokine in patients with chronic kidney disease

Figures & data

Table 1. Demographic characteristics of patients with CKD.

Subject	Age (yrs)	Height (cm)	Body Mass (kg)	BMI (kg/m^2)	AC (cm)	6MWT (m)	Hemodialysis (months)	Urea (mg/dL)	Creatinine (mg/dL)
S1	67	165.00	96	35.26	128	417	6.0	139.0	7.7
S2	63	160.00	93	36.32	128	343	120.0	80.0	6.8
S3	69	168.00	59	20.90	88	355	8.0	92.0	6.9
S4	65	168.00	52	18.42	82	342	12.0	124.0	6.0
S5	60	160.00	66	25.78	106	342	48.0	103.0	5.4
S6	68	158.00	57	22.83	100	330	24.0	171.0	8.7
S7	76	161.00	81	31.24	120	318	12.0	110.0	3.6
S8	56	159.00	78	30.85	109	177	12.0	194.0	8.1
S9	60	171.00	70	23.93	98	288	6.0	100.0	5.1
Mean (S.D.)	64.88 (1.98)	163.33 (1.58)	72.44 (5.22)	27.28 (2.12)	106.55 (5.49)	323.55 (21.60)	27.55 (12.36)	123.66 (12.64)	6.47 (0.53)

Note: AC, Abdominal circumference; BMI, body mass index; 6MWT, six-minute walk test.

Table 2. Cytokine response to endurance exercise intradialysis (EX) or control hemodialysis (CON) in peripheral blood of patients with CKD.

	Pre	During	Post
IL-6 (pg/mL)
EX	2.69 (1.70–3.68)	2.59 (1.61–3.57)	2.91 (2.43–3.38)
CON	3.03 (2.59–3.47)	3.25 (2.72–3.65)	2.96 (2.11–3.81)
IL-17A (pg/mL)
EX	2.32 (1.43–3.21)	2.10 (1.25–2.94)	3.56 (2.49–4.63)^b
CON	2.32 (1.20–3.44)	2.15 (1.28–2.93)	4.21 (3.38–5.15)^b
INF-γ (pg/mL)
EX	0.42 (0.19–0.64)	0.14 (0.08–0.21)	0.57 (0.29–0.84)^b
CON	0.53 (0.30–0.78)	0.22 (0.12–0.31)^a	0.78 (0.49–1.07)^b
TNF-α (pg/mL)
EX	1.62 (0.92–2.32)	1.02 (0.54–1.50)	1.18 (0.71–1.65)
CON	1.49 (1.06–1.93)	1.07 (0.50–1.50)	1.40 (1.24–1.55)
IL-10 (pg/mL)
EX	1.12 (0.47–1.77)	1.27 (0.49–2.04)	2.19 (1.27–3.12)^a,b
CON	1.34 (0.37–2.30)	0.75 (0.46–1.04)	1.60 (1.21–2.00)^b

Notes: Data presented as mean with 95% Confidence Interval. EX, Exercise session; CON, control session; IL, interleukin; INF-γ, interferon-gamma; TNF-α, tumoral necrosis factor-alpha.

^ap < 0.05, as compared with pre.

^bp < 0.05, as compared with during.

Figure 1. The relative changes of (a) TNF-α, (b) IL-17a, (c) INF-γ and (d) IL-10 concentrations to intradialytic exercise (circle) or control (square) HD session in patients with CKD. ^aA significant main effect of time (p<0.05). ^bA significant session effect (p < 0.05).