Figures & data
Figure 1. Histopathological changes of kidney tissue. (A) H&E staining, magnification × 200, (B) Masson trichrome staining, magnification × 200, (C) total renal histopathological score and (D) fibrotic area percentage. WT, wild-type; KO, SOST knockout. Each bar represented the mean ± standard deviation. *p < 0.05 versus shame control. #p < 0.05 time-matched UUO WT versus KO.
Figure 2. RT-PCR analysis result. (A) α-SMA (B) Col-I (C) FN. All mRNA expressions were normalized to GAPDH. WT, wild-type; KO, SOST knockout. Each bar represented the mean ± standard deviation. *p < 0.05 versus shame control. #p < 0.05 time-matched UUO WT versus KO.
Figure 3. Western-blot result. α-SMA, Col-I and FN protein expression levels were showed. All expressions were normalized to GAPDH. WT, wild-type; KO, SOST knockout.
