The effects of Panax notoginseng saponins on the cytokines and peritoneal function in rats with peritoneal fibrosis

Figures & data

Table 1. The change of body weight of rats in three groups.

Group	Number of rats	Initial weight (kg)	Weight before execution(kg)
Saline	7	169.1 ± 1.4	441.9 ± 5.1
Standard PDF	7	169.4 ± 2.7	444.9 ± 3.3
PNS	7	169.9 ± 1.3	446.9 ± 2.5

Table 2. The results of peritoneal function test of rats in three groups.

Group	Ultrafiltration (mL)	Di/Do	D/Purea
Saline	12.7 ± 1.5	0.75 ± 0.03	0.57 ± 0.01
Standard PDF	6.6 ± 0.7*	0.55 ± 0.02*	0.74 ± 0.02*
PNS	9.3 ± 0.45*△	0.66 ± 0.02*△	0.65 ± 0.01*△

*p < 0.05 compared with saline group.

△p < 0.05 compared with standard PDF group.

Table 3. The results of peritoneal function test of rats in three groups (mmol/L).

Group	Glucose	TG	TC	LDL	Abl
Saline	11.24 ± 0.11	0.65 ± 0.01	1.62 ± 0.03	0.46 ± 0.02	26.09 ± 1.41
Standard PDF	11.70 ± 0.17	0.64 ± 0.02	1.65 ± 0.02	0.45 ± 0.01	25.47 ± 1.10
PNS	11.05 ± 0.29	0.71 ± 0.03	1.64 ± 0.02	0.44 ± 0.02	25.90 ± 1.36

Figure 1. The morphologic changes of rat peritoneum on the effects of standard PDF and PNS. (A) Saline group, (B) Standard PDF group, and (C) PNS group.

Figure 2. Effects of PNS on the peritoneum tissue of rats examined by HE staining. (A) Saline group, (B) Standard PDF group, and (C) PNS group. Original magnification 200x.

Figure 3. Effects of PNS on the peritoneum tissue of rats examined by Masson's trichrome staining. (A) Saline group, (B) Standard PDF group, and (C) PNS group. Original magnification 200x.

Figure 4. Effects of PNS on the peritoneum tissue of rats examined by transmission electron microscope. (A) Saline group, (B) Standard PDF group, and (C) PNS group.

Table 4. The thickness of peritoneum tissue in 3 groups.

Group	Number of rats	Peritoneum thickness (μm)
Saline	7	15.4 ± 0.91
Standard PDF	7	55.3 ± 1.20*
PNS	7	33.6 ± 2.11*△

*p < 0.05 compared with saline group.

△p < 0.05 compared with standard PDF group.

Table 5. The concentration of cytokines of rats in three groups (pg/mL).

Group	TGF-β1	CTGF	MCP-1
Saline	51.67 ± 22.52	36.29 ± 7.56	28.51 ± 5.72
Standard  PDF	599.59 ± 195.29*	323.14 ± 115.43*	261.74 ± 78.80*
PNS	133.22 ± 40.51*△	112.32 ± 39.15*△	89.62 ± 38.23*△

*p < 0.05 compared with saline group.

△p < 0.05 compared with standard PDF group.