Comment on “Regional particle size dependent deposition of inhaled aerosols in rats and mice” by Kuehl et al.

Figures & data

Figure 1. Graphical representation of interception effect (left) and the combined interception-diffusion effect (right). In both cases, the larger (less dense) particle is collected as it contacts the wall, whereas the smaller particle is not. This is despite the two particles possessing the same aerodynamic diameter.

Table 1. Reported aerodynamic diameters used by Kuehl et al. and Raabe et al. and geometric diameters for both studies.

	Mass median aerodynamic diameter (µm)	Geometric diameter (approx.) (µm)
Kuehl et al.	0.5	0.5
	1.0	1.0
	3.0	3.0
	5.0	5.0
Raabe et al.^a	1.09 (mouse) 1.025 (rat)	0.5
	3.45 (mouse) 3.11 (rat)	1.7
	4.49 (mouse) 4.26 (rat)	3.0

^aReported as “Aerodynamic Resistance” diameter.

Figure 2. Geometric and MMA diameter plots of pulmonary deposition for both studies. The left panels are mouse data and right panels rat data.