Central Retinal Enrichment Supplementation Trials (CREST): Design and Methodology of the CREST Randomized Controlled Trials

Figures & data

FIGURE 1. Structure of the Central Retinal Enrichment Supplementation Trials (CREST) management and collaboration.

FIGURE 2. Central Retinal Enrichment Supplementation Trials (CREST) Trial 1 consolidated statement of reporting trials flow diagram.

FIGURE 3. Central Retinal Enrichment Supplementation Trials (CREST) Trial 2 consolidated standards of reporting trials flow diagram.

TABLE 1. Central Retinal Enrichment Supplementation Trials (CREST) study procedures in Trial 1.

Study procedures	Baseline	3 months	6 months	12 months
Demographic and lifestyle questionnaire	•
Subjective visual function questionnaire	•			•
Dietary carotenoid screener	•			•
Cognitive function assessment	•			•
Visual acuity assessment	•	•	•	•
Letter contrast sensitivity	•	•	•	•
Contrast sensitivity with functional vision analyzer	•	•	•	•
Light scatter	•	•	•	•
Photostress recovery	•	•	•	•
MP measurement by customized heterochromatic flicker photometry	•	•	•	•
MP measurement by dual-wave autofluorescence	•	•	•	•
Optical coherence tomography	•	•	•	•
Fundus photography	•	•	•	•
Serum carotenoid analysis	•	•	•	•

MP, macular pigment

TABLE 2. Central Retinal Enrichment Supplementation Trials (CREST) study procedures in Trial 2.

Study procedures	Baseline	6 months	12 months	18 months	24 months
Demographic and lifestyle questionnaire	•
NEI VFQ-25	•				•
Dietary carotenoid screener	•				•
Cognitive function assessment	•				•
Visual acuity assessment	•	•	•	•	•
Reading acuity	•	•	•	•	•
Reading speed	•	•	•	•	•
Letter contrast sensitivity	•	•	•	•	•
Contrast sensitivity with functional vision analyzer	•	•	•	•	•
Light scatter	•	•	•	•	•
Photostress recovery	•	•	•	•	•
MP measurement by customized heterochromatic flicker photometry	•	•	•	•	•
MP measurement by dual-wave autofluorescence	•	•	•	•	•
Optical coherence tomography	•	•	•	•	•
Fundus photography	•	•	•	•	•
Fundus grading	•				•
Serum carotenoid analysis	•	•	•	•	•

MP, macular pigment; NEI VFQ-25, 25-item National Eye Institute Visual Functioning Questionnaire