Does mean platelet volume predict the location of the infarct-related artery in non-ST-segment elevation myocardial infarction patients?

Figures & data

Table I. Patient characteristics.

	LAD group (n = 113)	Non-LAD group (n = 162)	p Value
Age (years)	66 ± 12	65 ± 12	0.53
Men	67 (59)	108 (67)	0.21
Hypertension	89 (79)	112 (69)	0.08
Diabetes	45 (40)	53 (33)	0.23
Hyperlipidemia	64 (57)	89 (55)	0.78
Current smoking	24 (21)	49 (30)	0.1
Previous MI	18 (16)	27 (17)	0.87
Previous PCI	39 (35)	56 (35)	0.99
TIMI risk score			0.97
Low risk 0–2	20 (18)	30 (19)
Medium risk 3–4	63 (56)	91 (56)
High risk 5–7	30 (27)	41 (25)
Hemodynamic and laboratory data
Killip class >1 on admission	15 (13)	15 (9)	0.29
Systolic blood pressure (mmHg)	144 ± 25	145 ± 26	0.88
Heart rate (beats/min)	82 [72–94]	78 [69–90]	0.16
White blood cell (10^3/µl)	8.8 [7.1–10.6]	8.3 [6.5–10.1]	0.11
Hemoglobin (g/dl)	13.1 [11.8–14.5]	13.6 [12.3–14.3]	0.4
Platelet (10^3/µl)	227 [171–266]	200 [171–234]	0.06
Mean platelet volume (fl)	8.6 [7.9–9.2]	8.4 [7.9–9.5]	0.72
Peak troponin I (µg/l)	0.81 [0.13–4.3]	1.79 [0.24–8.7]	0.02
Echocardiography data
LVEF	55 [43–60]	60 [50–65]	0.02
Angiographic findings
Three-vessel disease	21 (19)	40 (25)	0.23
TIMI grade 0 flow	10 (9)	30 (19)	0.03
TIMI grade 0–1 flow	17 (15)	51 (31)	0.002
Thrombus (TIMI grade 1–5)	33 (29)	96 (59)	<0.001
Thrombus (TIMI grade 4–5)	14 (12)	42 (26)	0.006
Collateral (Rentrop grade 2–3)	11 (10)	36 (22)	0.007
In-hospital events
In-hospital PCI	82 (73)	127 (78)	0.27
In-hospital CABG	7 (6)	17 (10)	0.21
In-hospital MACE	2 (2)	3 (2)	1
In-hospital heart failure	17 (15)	16 (10)	0.19
Cardiogenic shock	3 (3)	3 (2)	0.69
Length of stay	4.2 [2.5–6.4]	4.0 [2.3–7.6]	0.82
Mean platelet volume in subgroups
Subgroup
Age ≥65 years (n = 147)	8.5 [7.9–9.1]	8.4 [7.9–9.5]	0.64
Age <64 years (n = 128)	8.8 [8.0–9.2]	8.4 [7.9–9.5]	0.99
Men (n = 175)	8.6 [7.8–9.1]	8.3 [7.9–9.4]	1.00
Women (n = 100)	8.6 [8.1–9.3]	8.8 [8.2–9.8]	0.35
No previous MI (n = 230)	8.6 [7.9–9.2]	8.4 [7.9–9.5]	0.83

Data are expressed as number (percentage), mean ± SD, or median [interquartile range].

MI, myocardial infarction; PCI, percutaneous coronary intervention; TIMI, thrombolysis in myocardial infarction; LVEF, left ventricular ejection fraction; CABG, coronary artery bypass grafting; MACE, major adverse cardiac events.

Table II. Mean platelet volume in relation to angiographic findings.

Variable	Numbers of present	Present vs. absent	p value
LAD culprit	113	8.6 [7.9–9.2] vs. 8.4 [7.9–9.5]	0.72
LCX culprit	78	8.4 [7.9–9.6] vs. 8.5 [7.9–9.2]	0.91
RCA culprit	84	8.4 [8.0–9.4] vs. 8.5 [7.9–9.3]	0.78
TIMI grade 0 flow	40	8.3 [7.9–9.2] vs. 8.6 [7.9–9.4]	0.34
TIMI grades 0–1 flow	68	8.4 [7.9–9.3] vs. 8.6 [8.0–9.3]	0.69
Thrombus (TIMI grade 1–5)	129	8.5 [7.9–9.2] vs. 8.5 [8.0–9.4]	0.4
Thrombus (TIMI grade 4–5)	56	8.3 [7.8–9.2] vs. 8.6 [8.0–9.4]	0.13
Collateral (Rentrop grade 2–3)	47	8.2 [7.7–9.2] vs. 8.6 [8.0–9.4]	0.12

Data are expressed as median [interquartile range].

LAD, left anterior descending artery; LCX, left circumflex artery; RCA, right coronary artery; TIMI, thrombolysis in myocardial infarction.