Sleep characteristics, exercise capacity and physical activity in patients with chronic fatigue syndrome

Abstract

Purpose: Unrefreshing sleep and lowered physical activity are commonly observed in chronic fatigue syndrome (CFS) patients, but how they might influence each other remains unexplored. Therefore, this study simultaneously examined the exercise capacity, sleep characteristics and physical activity in CFS patients. Methods: Handgrip strength and cycle exercise capacity were assessed in 42 female CFS patients and 24 inactive control subjects. During four consecutive days and nights, energy expenditure, activity and sleep–wake pattern were objectively registered using a Sensewear Armband. Results: Exercise capacity was significantly lower in CFS patients. In both groups VO₂peak correlated with the time subjects were physically active. In CFS patients only, VO₂peak correlated negatively with sleeping during the day whilst physical activity level and energy expenditure correlated negatively with sleep latency and lying awake at night. Conclusions: In the present study, CFS patients with higher VO₂peak tend to sleep less over day. Occupation in physical activities was negatively associated with sleep latency and lying awake at night. Increased physical activity potentially has beneficial effects on sleep quality in CFS. However, a close monitoring of the effects of increasing physical activity is essential to avoid negative effects on the health status of patients.

Implications for Rehabilitation

• Female patients with chronic fatigue syndrome (CFS) have normal sleep latency and sleep efficiency, but sleep more and spent more time in bed as compared to healthy inactive women.

• Female CFS patients have lower exercise capacity, and a lower physical activity level as compared to healthy inactive women.

• CFS patients appear to be more sensitive for sleep quality (sleep latency and lying awake at night), which is associated with a low physical activity level.

• Exercise capacity
• fatigue
• functional strength
• physical activity
• sleep

Acknowledgements

The authors wish to express their gratitude to all who voluntary participated in this study.

Declaration of interest

The study was partly funded by ixX Pharma, Belgium.