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Stress
The International Journal on the Biology of Stress
Volume 18, 2015 - Issue 6
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Original Research Report

Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze

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Pages 677-685 | Received 25 Mar 2015, Accepted 12 Aug 2015, Published online: 21 Aug 2015

Figures & data

Figure 1. (a) Illustration of the nine arms 3D maze; (b) Raised arm configuration used in the present experiment; (c) Standard arm configuration; (d) Lowered arm configuration; (e) Angle of inclination of the bridge. B = bridge; A = arm; CP = central platform. See pictures of the maze in Ennaceur et al. (Citation2008b).

Figure 1. (a) Illustration of the nine arms 3D maze; (b) Raised arm configuration used in the present experiment; (c) Standard arm configuration; (d) Lowered arm configuration; (e) Angle of inclination of the bridge. B = bridge; A = arm; CP = central platform. See pictures of the maze in Ennaceur et al. (Citation2008b).

Figure 2. Post-hoc comparisons between groups (Student Newman–Keuls). Each data point represents the mean ± s.e.m of each group in each test session. SALAC = Saline acute (n = 8); SALCH = Saline chronic (n = 8); FLUCH = Fluoxetine chronic (n = 8); s1 to s3 = session 1 to session 3. (a) *FLUCH compared to SALCH and SALAC in s1 (p < 0.02); •SALAC compared to SALCH and FLUCH in s2 (p < 0.02) and s3 (p < 0.0002); (b) In s1, *FLUCH compared to SALAC (p < 0.02) and SALCH (p < 0.01); in s2, •SALAC compared to SALCH (0.05) and FLUCH (0.03); in s3, •SALAC compared to SALCH (p < 0.0001) and FLUCH (p < 0.0003), ♣FLUCH compared to SALCH (p < 0.04); (c) In s1, *FLUCH compared to SALAC (0.02) and to SALCH (p < 0.008); in s2, •SALAC compared to SALCH (0.03) and FLUCH (p < 0.05); in s3, ♦SALAC compared to SALCH (0.0002) and FLUCH (p < 0.0007), ♣SALCH compared to FLUCH (p < 0.07).

Figure 2. Post-hoc comparisons between groups (Student Newman–Keuls). Each data point represents the mean ± s.e.m of each group in each test session. SALAC = Saline acute (n = 8); SALCH = Saline chronic (n = 8); FLUCH = Fluoxetine chronic (n = 8); s1 to s3 = session 1 to session 3. (a) *FLUCH compared to SALCH and SALAC in s1 (p < 0.02); •SALAC compared to SALCH and FLUCH in s2 (p < 0.02) and s3 (p < 0.0002); (b) In s1, *FLUCH compared to SALAC (p < 0.02) and SALCH (p < 0.01); in s2, •SALAC compared to SALCH (0.05) and FLUCH (0.03); in s3, •SALAC compared to SALCH (p < 0.0001) and FLUCH (p < 0.0003), ♣FLUCH compared to SALCH (p < 0.04); (c) In s1, *FLUCH compared to SALAC (0.02) and to SALCH (p < 0.008); in s2, •SALAC compared to SALCH (0.03) and FLUCH (p < 0.05); in s3, ♦SALAC compared to SALCH (0.0002) and FLUCH (p < 0.0007), ♣SALCH compared to FLUCH (p < 0.07).

Figure 3. Post-hoc comparisons between groups (Student Newman–Keuls). Each data point represents the mean ± s.e.m of each group in each test session. SALAC = Saline acute (n = 8); SALCH = Saline chronic (n = 8); FLUCH = Fluoxetine chronic (n = 8); s1 to s3 = session 1 to session 3. (a) No significant differences between groups (p > 0.10); (b) *SALCH compared to SALAC and FLUCH in s1 (p < 0.02) and •SALCH compared to SALAC in s3 (p < 0.05); (c) *FLUCH compared to SALAC and SALCH in s1 (p < 0.02); •SALAC compared to SALCH and FLUCH in s2 (p < 0.05) and s3 (p < 0.001).

Figure 3. Post-hoc comparisons between groups (Student Newman–Keuls). Each data point represents the mean ± s.e.m of each group in each test session. SALAC = Saline acute (n = 8); SALCH = Saline chronic (n = 8); FLUCH = Fluoxetine chronic (n = 8); s1 to s3 = session 1 to session 3. (a) No significant differences between groups (p > 0.10); (b) *SALCH compared to SALAC and FLUCH in s1 (p < 0.02) and •SALCH compared to SALAC in s3 (p < 0.05); (c) *FLUCH compared to SALAC and SALCH in s1 (p < 0.02); •SALAC compared to SALCH and FLUCH in s2 (p < 0.05) and s3 (p < 0.001).

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