A 21st century roadmap for human health risk assessment

Figures & data

Figure 1. The RISK21 roadmap. This diagram is a schematic representation of a multifunctional tool that provides a transparent process for obtaining rational risk-related decision points. The inverted triangles for exposure and toxicity represent the proportional investment of resources needed for each tier. The following steps describe the use of the roadmap and are described in additional detail in Embry et al. (2014): 1) Problem formulation: Define problem. This initial step is reevaluated throughout the iterative process; 2) Exposure estimate: Obtain tiered estimate of exposure BEFORE assessing toxicity. Use existing knowledge. Express as range; 3) Toxicity estimate: Obtain tiered estimate of toxicity. Use existing knowledge. Develop data only as needed. Express as range; 4) Matrix: Intersect exposure and toxicity estimates on the matrix.

Embry MR, Bachman AN, Bell DR, Boobis AR, Cohen SM, Dellarco M, et al. (2014). Risk Assessment in the 21st Century: Roadmap and Matrix.Crit Rev Toxicol, 44, 6–16.

 Google Scholar