Carcinogenic risk of retained arsenic after successful treatment of acute promyelocytic leukemia with arsenic trioxide: a cause for concern?

Figures & data

Figure 1. Enzymatic steps in the conversion of inorganic to methylated arsenic in the human [6]. Reprinted with permission from the publisher.

Aposhian H, Zakharyan H, Avram M, et al. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Toxicol Appl Pharmacol 2004;198:327–335.

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