Figures & data
Table 1. Composition of aceclofenac ocular inserts.
Table 2. Scoring chart for HET-CAM test.
Table 3. Lid closure scores for evaluation of in vivo ocular anti-inflammatory study done in rabbit eye model after PGE2-induced inflammation.
Table 4. Physicochemical parameters of ocular gelatin films.
Table 5. Folding endurance, tensile strength, percentage elongation, and percentage equilibrium swelling of ocular films.
Figure 1: FTIR spectra of A) Pure aceclofenac; B) Non cross linked gelatin film (AF5); C) Non Sterilized Cross linked gelatin film (AF8) D) Sterilized Cross linked gelatin film (AF8)
Figure 2: In vitro drug release profiles of ocular inserts containing aceclofenac.
Table 6. Kinetic modeling of drug release data from ocular inserts of aceclofenac.
Table 7. Scores obtained in HET-CAM test.
Figure 3: In vivo drug release profiles of ocular inserts containing aceclofenac.
Figure 4: Scatter diagram showing in vitro and in vivo correlations of ocular inserts containing aceclofenac (r = 0.9976).
Table 8. Comparison of effect of the aceclofenac ocular film with eye drop of drug at the same concentration on PGE2-induced lid closure in rabbit eye. For each group of tested dosage form, the left eye was treated as test (either eye drop or ocular insert) and right eye as control (normal saline).
Figure 5: Comparison of effect of Aceclofenac Ocular film with aqueous solution of drug on PGE2 induced PMN migration in tears of rabbit. For each group of tested dosage form, left eye was treated as test (either eye drop or ocular insert) and right eye as control (normal saline)
