Figures & data
Figure 1. Structure of thymoquinone (TQ).
Figure 2. Electron microscopic images for extruded TQ encapsulated liposomes; (A) SEM image (B) TEM image. The average diameter of liposomes is about 100 nm.
Figure 3. Optical microscope image of non-extruded TQ-LP.
Figure 4. 1H-NMR spectrum for A) DPPC and B) DPPC + TQ mixture in CDCl3.
Figure 5. 1H-NMR spectrum for TQ in CDCl3.
Figure 6. 1H-NMR spectrum for TQ-LP in CDCl3.
Figure 7. Differential scanning calorimetry (DSC) analysis. The melting temperatures (Tm) (sharp peaks) of liposomes are compared. The Tm of DPPC liposome (41.8°C) was decreased by 2°C compared with DPPC-Triton X100 liposome (39.8°C).
Figure 8. Anti-proliferative effects of liposomal TQ on cell lines MCF-7 (A) T47D (B) and PLF (C). Readings are the mean of two replicate experiments each was done in triplicate.
Figure 9. Comparison of cytotoxicity between liposomal TQ, free TQ and empty liposomes on periodontal ligament fibroblasts cells (a), MCF-7 (b) and T47D (c).
Figure 10. The in vitro release of thymoquinone from TQ-LP liposomes.
