Enhanced delivery of gentamicin to infection foci due to Staphylococcus aureus using gold nanorods

Figures & data

Figure 1. A schematic representation of gold nanorods–gentamicin conjugation.

Figure 2. Infrared spectra of gentamicin (A) and gentamicin–GNRs complex (B). Shifting of NH₂ stretching frequency to a higher wavelength means direct binding of nitrogen atoms of free amino groups of gentamicin molecules to gold nanorods.

Figure 3. Typical chromatograms of the developed HPLC method.

Table 1. Results of atomic absorption analysis.

Sample	Concentration
Gold nanorods	1.87
Gold nanorods attached to gentamicin	0.18

Table 2. MIC and MBC of gentamicin and gentamicin–GNRs complex against S. aureus.

Sample	MIC (μg ml^−1)	MBC (μg ml^−1)
Gentamicin	15.62	31.24
Gentamicin–gold nanorods	7.812	15.62

Figure 4. Biodistribution data in vital organs of infected BALB/c mice at time intervals of 10, 20, 30 and 60 min post-injection of gentamicin–GNRs complex.