Design of novel multifunctional targeting nano-carrier drug delivery system based on CD44 receptor and tumor microenvironment pH condition

Figures & data

Figure 1. Schematic illustration of the formation, accumulation at tumor site and drug delivery of self-assembled oHM nanoparticles (oHMN).

Figure 2. Synthesis of multifunctional oHM.

Figure 3. ¹H NMR spectra of oHM.

Figure 4. The external physical properties (A), AFM (B), TEM (C) of oHM nanoparticles (oHMN).

Table 1. The physicochemical parameters of Cur-oHMN before freeze-drying and after freeze-drying.

Parameters	Before freeze-drying	After freeze-drying
Entrapment efficiency (%)	57.6 ± 4.8	42.3 ± 6.5
Particle size (nm)	128.6 ± 7.4	165.2 ± 8.3
Zeta potential (mv)	−27.7 ± 2.3	−16.2 ± 2.6

Figure 5. Percentage of curcumin released from oHMN at different pH condition.

Figure 6. Effect on the inhibition of tumor growth of Cur formulations. Each data represent the mean ± SD (n = 6). *p < 0.05, compared with the free saline.