Figures & data
Figure 1. Dexamethasone sodium phosphate (DEXP) sustained-release studies in vitro. (A) The periocular capsular drug delivery system (DDS) consisted of a capsule, a tube and a valve. (B) DEXP at concentrations of 2 mg/ml and 5 mg/ml was injected into the periocular capsular DDS, which were immersed in balanced salt solution (BSS) in modified Franz diffusion cells. Four-hundred microliter liquid was aspirated at 0.5, 1, 2, 4, 8, 24 and 48 h.
Figure 2. Periocular capsular drug delivery system (DDS) was implanted to the sub-Tenon's sac of rabbit eye. (A) The sub-Tenon's sac was exposed, (B) the periocular capsular DDS was laid in the sub-Tenon's sac, (C) the periocular capsular DDS was fixed on the episclera, (D) the dexamethasone sodium phosphate (DEXP) was injected through the valve and tube to the capsule of the periocular capsular DDS, (E) the schematic diagram of the periocular capsular DDS implanted to sub-Tenon's sac of the upper view and (F) the schematic diagram of the periocular capsular DDS implanted to sub-Tenon's sac of the lateral view.
Figure 3. The production mass spectra of dexamethasone sodium phosphate (DEXP). The ion transition of mass-to-charge ratio (m/z) 471.3 → 78.6 was chosen as the production for monitoring DEXP.
Figure 4. Representative ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) chromatograms of dexamethasone sodium phosphate (DEXP). (A) Balanced salt solution (BSS) in vitro, (B) blank BSS with standard DEXP in vitro, (C) samples in vitro, (D) blank tissue sample in vivo, (E) standard DEXP in blank tissue in vivo and (F) tissue samples in vivo.
Table 1. Summary of accuracy and precision of quaility control samples in UPLC-MS/MS detection of dexamethasone sodium phosphate (DEXP).
Figure 5. The cumulative release profile of dexamethasone sodium phosphate (DEXP). The periocular drug delivery system can release dexamethasone sodium phosphate in a time-dependent manner in vitro in the 2 mg/ml and 5 mg/ml groups in vitro.
Figure 6. Clinical observations after the drug delivery system implantation in the Tenon's sac of rabbit eye. (A) Slip lamp photography, slight inflammation was found in the first two weeks after surgery after implantation; (B) Fundus photography, no obvious change of the fundus was found after implantation; and (C) no significant change of IOP found after implantation (p > 0.05). *d, days.
