Figures & data
Figure 1. Schematic of trastuzumab-Maytansine (T-DM1) including the [N-maleimidomethyl]cyclohexane-1-carboxylate (MCC) linker. An average of 3.5 DM1 molecules are conjugated to the Fc region of trastuzumab (Adapted from Krop et al., 2012).
![Figure 1. Schematic of trastuzumab-Maytansine (T-DM1) including the [N-maleimidomethyl]cyclohexane-1-carboxylate (MCC) linker. An average of 3.5 DM1 molecules are conjugated to the Fc region of trastuzumab (Adapted from Krop et al., 2012).](/cms/asset/c792c55e-3961-4ab9-ae21-b228a681a436/idrd_a_998323_f0001_c.jpg)
Figure 2. Composition of brentuximab vedotin (cAC10-vcMMAE, SGN-35). SGN-30 (cAC10, the parent naked antibody) is a chimeric anti-CD30 monoclonal antibody derived from the fusion of the variable heavy and light region of the murine anti-CD30 antibody AC10, with the constant gamma1-heavy and kappa-light region of the human immunoglobulin (Adapted from Wahl et al., Citation2002; Doronina et al., Citation2006).
