Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging

Figures & data

Figure 1. FTIR spectra of naked Fe₃O₄ particles (a), PEI-Fe₃O₄ (b), and FA-PEI-Fe₃O₄ (c).

Figure 2. TEM images of naked Fe₃O₄ (a), PEI-Fe₃O₄ (b), and FA-PEI-Fe₃O₄ (c).

Figure 3. Thermogravimetric analysis (TGA) of naked Fe₃O₄ (a), PEI-Fe₃O₄ (b), and FA-PEI-Fe₃O₄ (c).

Figure 4. Magnetization curve of naked Fe₃O₄ (a), PEI-Fe₃O₄ (b) and FA-PEI-Fe₃O₄ (c) at room temperature..

Figure 5. Concentration dependent T₂-weighted MRI of FA-PEI-Fe₃O₄ in aqueous solution (a). Graph of relaxivity (R₂) versus FA-PEI-Fe₃O₄ concentration (b).

Figure 6. Cellular uptake of FA-PEI-Fe₃O₄ and PEI-Fe₃O₄ without free FA or with free FA by KB cells, MCF7 cells and L929 cells. (*p < 0.05).

Figure 7. MRI of KB cells and MCF7 cells after incubation with FA-PEI-Fe₃O₄ or PEI-Fe₃O₄.

Figure 8. T₂-weighted images of tumor-bearing nude mice pre-injection (a) and post-injection (b) of FA-PEI-Fe₃O₄.