Figures & data
Table 1. Composition, drug entrapment efficiency and vesicles diameter of carvedilol-loaded transfersomes.
Figure 1. In vitro release profiles of carvedilol from its transfersomal formulae: (A) T1–T6, (B) T7–T12, and (C) T13–T15.
Figure 2. Permeation profiles of carvedilol from transfersomal formulae: (A) T1–T6, (B) T7–T12, and (C) T13–T15.
Table 2. Ex vivo permeation parameters of carvedilol-loaded transfersomes versus carvedilol solution.
Figure 3. Confocal images of cross-sections of nasal mucosa after application of (A) rhodamine-loaded transfersomes (T14) and (B) rhodamine solution.
Figure 4. Transmission electron micrograph of formula T14.
Figure 5. Effect of storage on the amount of carvedilol retained and vesicle size of transfersomal formula T14.
Figure 6. Light photomicrographs of (A) untreated rat epithelium (B) rat epithelium treated with in situ gelling of carvedilol-loaded transfersomal formula T14.
Figure 7. Mean carvedilol concentrations in plasma of rabbits after administration of IV solution, in situ gelling transfersomal formula T14 and oral suspension.
