Folate-modified, cisplatin-loaded lipid carriers for cervical cancer chemotherapy

Figures & data

Table 1. Characterization of different vectors.

Samples	Blank NLCs	CIS-NLCs	FA-CIS-NLCs
Particle size (nm)	116.2 ± 2.9	119.6 ± 3.6	143.2 ± 5.3
Size distribution	0.08 ± 0.01	0.11 ± 0.01	0.15 ± 0.02
Zeta potential (mV)	+11.3 ± 1.2	+34.5 ± 3.1	+25.7 ± 2.3
EE (%)	N/A	89.2 ± 2.9	87.5 ± 3.2
LC (%)	N/A	11.3 ± 0.8	9.3 ± 0.6

Figure 1. CIS release profiles.

Table 2. IC₅₀ of FA-CIS-NLCs, CIS-NLCs and Free CIS evaluated in HeLa cells.

Samples	FA-CIS-NLCs	CIS-NLCs	Free CIS
IC50 values (µM)	0.75 ± 0.06	2.16 ± 0.25	6.59 ± 0.47

Figure 2. Tumor growth curves.

Table 3. TIRs of FA-CIS-NLCs, CIS-NLCs and Free CIS.

Samples	FA-CIS-NLCs	CIS-NLCs	Free CIS
TIR (%)	79.3 ± 3.6	64.4 ± 2.8	18.5 ± 1.3

Figure 3. Body weight changes.