Comparative study between simple and optimized liposomal dispersion of quetiapine fumarate for diffusion through nasal route

Figures & data

Figure 1. (a) Microscopic image of Simple dispersion of QTF (1500×). (b) SEM of simple dispersion of QTF. (c) TEM of simple dispersion of QTF. (d) Microscopic image of liposomal dispersion of QTF (1500×). (e) SEM of liposomal dispersion of QTF. (f) TEM of liposomal dispersion of QTF.

Figure 2. (a) Particle size distribution of simple dispersion. (b) Zeta potential distribution of simple dispersion. (c) Particle size distribution of liposomal dispersion. (d) Zeta potential distribution of liposomal dispersion.

Table 1. Ex vivo % drug diffusion (n = 3).

Time (h)	QTF dispersion	QTF liposomes
0	0	0
1	11.45 ± 0.71	6.40 ± 0.82800
2	17.76 ± 0.83	13.82 ± 2.02100
3	22.53 ± 1.22	24.01 ± 1.90450
4	25.82 ± 1.86	28.7 ± 1.10000
5	27.23 ± 1.17	31.80 ± 1.55050
6	27.56 ± 1.33	32.61 ± 1.70000

Figure 3. % Drug diffusion of simple and liposomal dispersion.

Figure 4. Gamma scintigraphy of (a) simple and (b) liposomal dispersion in mice.

Figure 5. Amount of QTF in brain homogenate (ng) of simple and liposomal dispersion (n = 3).

Figure 6. Nasal histopathological images of (a) negative control. (b) QTF simple dispersion. (c) QTF liposomal dispersion. (d) Positive control.