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Research Article

Nanostructured lipid carrier in photodynamic therapy for the treatment of basal-cell carcinoma

, , , , , & show all
Pages 1476-1485 | Received 10 Jan 2016, Accepted 09 Mar 2016, Published online: 05 Apr 2016

Figures & data

Figure 1. Pseudo-ternary phase diagram showing concentration of lipid and surfactant of nanoemulsion formation.

Figure 1. Pseudo-ternary phase diagram showing concentration of lipid and surfactant of nanoemulsion formation.

Table 1. Optimization parameter for drug-loaded NLC.

Figure 2. DSC scan of (a) Compritol ATO 888; (b) drug; (c) physical mixture; (d) drug-loaded NLC.

Figure 2. DSC scan of (a) Compritol ATO 888; (b) drug; (c) physical mixture; (d) drug-loaded NLC.

Table 2. Optimized formula of 5-ALA NLC.

Figure 3. In vitro release of drug from NLC1B and drug solution at pH 5.

Figure 3. In vitro release of drug from NLC1B and drug solution at pH 5.

Figure 4. Permeation study of 5-ALA-loaded NLC in PBS at pH 5.

Figure 4. Permeation study of 5-ALA-loaded NLC in PBS at pH 5.

Figure 5. The effect of NLC over aqueous control on cell viability at different concentrations.

Figure 5. The effect of NLC over aqueous control on cell viability at different concentrations.

Figure 6. (a) z-axis image of control-treated irradiated group (b): z-axis image of NLC-treated irradiated group (c) z-axis image of NLC-treated nonirradiated group.

Figure 6. (a) z-axis image of control-treated irradiated group (b): z-axis image of NLC-treated irradiated group (c) z-axis image of NLC-treated nonirradiated group.

Figure 7. (a) CLSM image of control-treated irradiated group (b) CLSM image of NLC-treated nonirradiated group (c) CLSM image of NLC-treated irradiated group.

Figure 7. (a) CLSM image of control-treated irradiated group (b) CLSM image of NLC-treated nonirradiated group (c) CLSM image of NLC-treated irradiated group.

Table 3. Results of in vivo studies.

Figure 8. Role of NLC in enhancing PDT efficacy of 5-ALA.

Figure 8. Role of NLC in enhancing PDT efficacy of 5-ALA.

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