Resuscitation with polymerized human placenta hemoglobin attenuated hemorrhagic shock-induced lung injury

Figures & data

Figure 1. The PaO₂/FiO₂ at baseline and during the period of resuscitation. Values were presented as mean ± SD (n = 15–18). ***P< 0.001 and **P< 0.01 vs. the HES group; ^†P< 0.05 vs. the whole blood group. PaO₂/FiO2: the ratio of arterial oxygen tension /fraction of inspire oxygen.

Table I. Mean arterial pressure throughout the study of the three groups.

Group	Mean Arterial Pressure
	At baseline	During shock	2 h after resuscitation
HES	125.16 ± 10.73	30.41 ± 1.23	43.46 ± 12.92
Whole blood	127.21 ± 11.06	30.22 ± 1.25	115.14 ± 13.52***
PolyPHb	127.73 ± 12.44	30.32 ± 1.26	92.18 ± 12.13**,†

Values were expressed as Mean ± SD (n = 15–18). ***P< 0.001 vs. the HES group; ^†P< 0.05 vs. the whole blood group.

Figure 2. The counts of WBC (A) and neutrophils (B) in blood. The levels of TNF-α (C) and IL-8 (D) in the lung tissue. Values were presented as mean ± SD (n = 15–18). **P< 0.01 and *P< 0.05 vs. the HES group; ^†P< 0.05 vs. the whole blood group. IL: interleukin; TNF: tumor necrosis factor; WBC: white blood cell.

Figure 3. A-D, Representative photomicrographs of H&E-stained left lung tissue sections (40x) harvested after 2 h of resuscitation. E, the W/D ratio of the three groups. Values were presented as mean ± SD (n = 15–18). *P< 0.05 vs. the HES group. H&E: Hematoxylin and Eosin; W/D ratio: the ratio of wet weight/dry weight.