Genotyping of IL-8-251 T > A yields prognostic information in patients with gastric carcinoma

Figures & data

Table 1. Association between IL-8-251 genotype and clinicopathologic factors.

		IL-8-251 T > A genotype
Factors	Patients	A/A No. (%)	A/T No.	T/T No.	p Value
Gender
Male	142	17 (8.1%)	58 (27.6%)	67 (31.9%)	0.446
Female	68	6 (2.9%)	34 (16.2%)	28 (13.3%)
Age
<60	111	9 (4.3%)	55 (26.2%)	49 (23.3%)	0.143
≥60	99	14 (6.7%)	37 (17.6%)	46 (21.9%)
Tumor size
≥5 cm	133	14 (6.7%)	53 (25.2%)	66 (31.4%)	0.308
<5 cm	77	9 (4.3%)	39 (18.6%)	29 (13.8%)
Depth of invasion
T1/T2	49	2 (1.0%)	30 (14.3%)	20 (9.5%)	0.007
T3/T4	137	21 (10.0%)	62 (29.5%)	75 (35.7%)
Lymph node metastasis
N0	83	6 (2.9%)	36 (17.1%)	42 (20.0%)	0.244
N1	127	17 (8.1%)	56 (26.7%)	53 (25.2%)
Distant metastasis
M1	21	2 (1.0%)	7 (3.3%)	11 (5.2%)	0.809
M0	189	21 (10.0%)	85 (40.5%)	84 (40.0%)
Lymphovascular invasion
V(+)	94	12 (5.7%)	46 (21.9%)	36 (17.1%)	0.167
V(−)	116	11 (5.2%)	46 (21.9%)	59 (28.1%)
Lauren classification
Poor	70	6 (2.9%)	32 (15.2%)	32 (15.2%)	0.527
Moderate	97	10 (4.8%)	46 (21.9%)	41 (19.5%)
Well	43	7 (3.3%)	14 (6.7%)	22 (10.5%)
Differentiation
Poor	133	17 (8.1%)	52 (24.8%)	63 (30.0%)	0.002
Moderate	43	6 (2.9%)	14 (6.7%)	22 (10.5%)
Well	34	0 (0%)	26 (12.3%)	10 (4.8%)
TNM stage
I	34	0 (0%)	23 (11.0%)	14 (6.7%)	0.009
II	52	7 (3.3%)	20 (9.5%)	23 (11.0%)
III	64	8 (3.8%)	32 (15.2%)	24 (11.4%)
IV	60	8 (3.8%)	17 (8.1%)	34 (16.2%)

Figure 1.  Overall survival curves according to genotype of the IL-8-251 polymorphism in gastric carcinoma patients. Significant differences were observed between the A/A genotype and A/T & T/T genotype groups.

Table 2.  Multivariate analysis of the prognostic impact of the IL-8-251 T > A polymorphism by the Cox proportional hazard model with a backward stepwise procedure.

Variables	p Value	Relative risk	95% CI^a
Tumor size	0.602	0.849	0.460–1.568
Lymphovascular invasion	0.273	1.414	0.761–2.625
Differentiation	0.198	1.293	0.874–1.912
Lauren classification	0.915	0.976	0.621–1.533
TNM stage
II/I	0.431	1.898	0.386–9.343
III/I	0.463	1.992	0.316–12.558
IV/I	0.176	3.468	0.572–21.013
III/II	0.020	2.726	1.171–6.34
II/IV	0.294	0.547	0.178–1.687
III/IV	0.095	0.574	0.299–1.102
IL-8-251 A/A genotype	0.035	2.285	1.060–4.926

^aConfidence interval.