Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients

Figures & data

Figure 1.  Serum FT levels of 41 patients with LOH. FT levels significantly elevated from 6.82 ± 1.51 to 8.24 ± 2.84 pg/ml after 3 months TRT with GL 6 mg/day (P = 0.0047; paired t-test).

Figure 2.  (a) Total AMS score significantly improved from 53.2 ± 9.4 to 42.7 ± 12.2 by TRT (P<0.0001; paired t-test). (b) All three domains of AMS (psychological, physiological and sexual) were relieved after TRT (all P < 0.0001; paired t-test).

Figure 3.  IIEF-5 scores have significantly raised from 9.2 ± 6.6 to 13.4 ± 8.3 after 3 months GL application (P = 0.0001; paired t-test).

Figure 4.  In SF-36 domains, physical functioning (PF), role physical (RP), bodily pain (BP), general health (GH), vitality (VT), social functioning (SF), role emotional (RE) and mental health (MH)) levels were lower than average before TRT. After 3 months TRT, PF (P < 0.01), GH (P < 0.0001), VT (P < 0.005), SF (P < 0.005), RE (P < 0.05) and MH (P < 0.0005) data showed significant improvement.

Table I. All parameters of total IPSS, post-voiding, storage, voiding and QOL were improved by TRT.

	Before TRT	After TRT	P-value
Total IPSS	8.537 ± 6.523	5.976 ± 5.420	0.0086
Post-voiding (Q 1)	0.951 ± 1.139	0.610 ± 0.945	0.0330
Storage (Q 2,4,7)	3.707 ± 2.994	2.878 ± 2.441	0.0483
Voiding (Q 3,5,6)	3.707 ± 3.655	2.512 ± 3.001	0.0280
QOL	3.317 ± 1.556	2.805 ± 1.537	0.0276

Mean ± SD before and after TRT are shown. Each P-value (paired t-test) is also indicated in the table.