Oxidative stress increases continuously with BMI and age with unfavourable profiles in males

Figures & data

Figure 1.  Relationship between BMI and age.

Figure 2.  Bilirubin, uric acid and TAS in relation to BMI categories.

Figure 3.  Linear correlation between TAS and uric acid.

Figure 4.  Lipid status (total cholesterol, LDL, HDL) related to BMI categories.

Figure 5.  Lipid peroxidation biomarkers (peroxides and oLAb) in relation to BMI categories.

Table I.  Baseline characteristics of the study sample including sex-specific differences.

	Males (N = 907)	Females (N = 1283)	Significance
Age (y)	43 ± 13 (17–83)	41 ± 12 (17–79)	p = 0.01^a
BMI (kg/m^2)	26.25 ± 4.39	24.41 ± 5.08	p < 0.001***
Total cholesterol (mg/dl)	208 ± 43	205 ± 38	p = 0.113 n.s.
LDL (mg/dl)	119 ± 38	111 ± 34	p < 0.001***
HDL (mg/dl)	57 ± 14	71 ± 17	p < 0.001***
HDL/LDL ratio	0.481 (0.365; 0.645)	0.653 (0.485; 0.85)	p < 0.001***
Bilirubin (mg/dl)	0.76 ± 0.48	0.57 ± 0.32	p < 0.001***
Uric acid (mg/dl)	5.71 ± 1.16	4.03 ± 0.96	p < 0.001***
TAS (mmol/l)	1.52 ± 0.11	1.44 ± 0.10	p < 0.001***
Peroxides (µmol H2O2 equ.)	61 ± 98	174 ± 226	p < 0.001***
oLAb (mU/ml)	485 ± 363	513 ± 369	p = n.s.

t Test was used if normality testing passed. Mann–Whitney Rank Sum Test was used if normality testing failed.

All numbers are mean ± SD with the exception of HDL/LDL ratio (median, 25% and 75% intervals).

^aAge was not significant after Bonferroni correction.

Abbreviations: BMI, body mass index; HDL, high-density lipoprotein; LDL, low-density lipoprotein; oLAb, oxidized low-density lipoprotein; TAS, total antioxidant status.