Are the Aging Male’s Symptoms (AMS) scale and the Androgen Deficiency in the Aging Male (ADAM) questionnaire suitable for the screening of late-onset hypogonadism in aging Chinese men?

Figures & data

Table 1. Summaries of AMS, ADAM scores and sex hormone levels.

	N (%)	Mean	SD
	985
AMS scores
Positive	568 (57.66%)
Negative	417 (42.34%)
ADAM scores
Positive	824 (83.65%)
Negative	161 (16.35%)
TT (ng/dl)		443.95	133.53
FT (ng/dl)		8.21	2.64
LH (IU/l)		5.69	3.05
FSH (U/l)		11.34	7.36
E2 (pg/ml)		34.67	14.71
PRL (μg/l)		10.83	7.69
SHBG (nmol/l)		44.87	23.77
BT (ng/dl)		174.8	61.48

Table 2. Correlation of age, AMS scores and sex hormone levels.

Correlation		AMS score
coefficient	Age	Psychological	Somatic	Sexual	Total
Age (years)	–	0.02	0.14***	0.39***	0.26***
TT (ng/dl)	−0.04	−0.05	−0.02	−0.02	−0.05
FT (ng/dl)	−0.30***	−0.06	−0.04	−0.12**	−0.12***
LH (IU/l)	0.32***	−0.01	0.06	0.15***	0.11**
FSH (U/l)	0.37***	0.02	0.08	0.15**	0.12***
E2 (pg/ml)	0.06	−0.01	−0.02	0.03	−0.01
PRL (μg/L)	−0.05	0.01	0.01	0.06	0.03
SHBG (nmol/l)	0.31***	−0.01	0.02	0.12**	0.08*
BT (ng/dl)	−0.34***	−0.04	−0.04	−0.12**	−0.11**

*p < 0.05; **p < 0.01; ***p < 0.001.

Table 3. Association of age, severity of the symptoms according to the AMS score and sex hormonal levels.

	AMS score
Variables	No/little	Mild	Moderate	Severe
Age (years) *	57.64 ± 6.95	59.95 ± 7.21	62.44 ± 7.90	61.92 ± 7.69
TT (ng/dl)	447.60 ± 122.97	442.19 ± 138.40	435.90 ± 141.01	454.39 ± 160.79
FT (ng/dl)	8.49 ± 2.48	7.98 ± 2.68	8.02 ± 2.93	8.34 ± 2.49
LH (IU/l)*	5.34 ± 2.60	5.79 ± 2.98	6.06 ± 4.10	6.91 ± 3.04
FSH (U/l)	10.48 ± 6.63	12.17 ± 8.52	11.63 ± 6.08	10.55 ± 5.07
E2 (pg/ml)	34.73 ± 14.50	34.10 ± 13.90	36.15 ± 17.08	34.21 ± 15.82
PRL (μg/l)	10.99 ± 9.27	10.21 ± 5.22	11.76 ± 8.38	12.07 ± 7.02
SHBG (nmol/l)	42.71 ± 21.17	46.34 ± 23.65	47.03 ± 30.36	44.79 ± 21.58
BT (ng/dl)	182.33 ± 57.51	168.09 ± 61.76	171.48 ± 70.25	178.08 ± 56.75

*p < 0.001

Table 4. Asociation of age, AMS, ADAM scores, and sex hormone levels.

	AMS		ADAM
Associations	Positive	Negative	Positive	Negative
Age (years)	60.72 ± 7.50	57.64 ± 6.95***	60.19 ± 7.26	55.33 ± 6.97***
TT (ng/dl)	441.44 ± 140.40	447.60 ± 122.97	442.90 ± 135.04	450.07 ± 124.78
FT (ng/dl)	8.02 ± 2.73	8.49 ± 2.48***	8.09 ± 2.62	8.90 ± 2.63**
LH (IU/l)	5.94 ± 3.30	5.34 ± 2.60**	5.81 ± 3.15	5.03 ± 2.25*
FSH (U/l)	11.92 ± 7.78	10.48 ± 6.63***	11.60 ± 7.64	9.83 ± 5.24*
E2 (pg/ml)	34.62 ± 14.87	34.73 ± 14.50	34.52 ± 14.38	35.48 ± 16.41
PRL (μg/l)	10.71 ± 6.31	10.99 ± 9.27	10.75 ± 7.92	11.29 ± 6.33
SHBG (nmol/l)	46.42 ± 25.39	42.71 ± 21.17*	45.61 ± 24.31	40.90 ± 20.28**
BT (ng/dl)	169.62 ± 63.61	182.33 ± 57.51***	171.94 ± 61.08	191.46 ± 61.39**

*p < 0.05; **p < 0.01; ***p < 0.001.

Table 5. The sensitivity and specificity of the AMS scale and ADAM questionnaire.

	AMS						ADAM
	Positive	Negative	Sensitivity	Specificity	PPV	NPV	Positive	Negative	Sensitivity	Specificity	PPV	NPV
TT < 300 ng/dl and  FT < 5 ng/dl	127	108	0.540	0.412	0.224	0.741	185	50	0.787	0.148	0.225	0.689
Others	441	309					639	111
Total	568	417					824	161
TT < 300 ng/dl	178	140	0.560	0.415	0.313	0.664	260	58	0.818	0.154	0.316	0.640
TT ≥ 300 ng/dl	390	277					564	103
Total	568	417					824	161