Comprehensive evaluation of androgen replacement therapy in aging Japanese men with late-onset hypogonadism

Figures & data

Table 1. Changes in various parameters after ART.

	Baseline	Month six	p Value
Testosterone (ng/mL)	5.1 ± 1.8	12.2 ± 4.4	<0.001
Free-testosterone (pg/mL)	6.4 ± 2.5	21.6 ±8.9	<0.001
Total cholesterol (mg/dL)	201.4 ± 34.2	184.8 ± 34.2	<0.001
LDL-cholesterol (mg/dL)	115.6 ± 33.2	105.4 ± 33.6	0.0068
HDL-cholesterol (mg/dL)	62.4 ± 15.7	58.6 ± 14.1	0.10
AST (IU/L)	23.9 ± 8.6	21.6 ± 6.7	0.076
ALT (IU/L)	26.8 ± 14.6	22.8 ± 11.7	0.070
γ-GTP (IU/L)	78.9 ± 150.0	51.4 ± 74.7	0.12
Glucose (mg/dL)	108.6 ± 21.7	107.6 ± 25.4	0.81
HbA1c (%)	5.3 ± 0.58	5.4 ± 0.58	0.20
Red blood cell (10^4/μL)	468.7 ± 54.9	485.1 ± 57.4	<0.001
Hemoglobin (g/dL)	14.3 ± 1.3	14.7 ± 1.3	<0.001
Hematocrit (%)	42.7 ± 3.5	44.1 ± 4.1	<0.001
PSA (ng/mL)	0.79 ± 0.39	1.0 ± 0.61	<0.001
Prostate volume (mL)	17.0 ± 7.0	17.3 ± 5.6	0.73
Residual urine volume (mL)	11.3 ± 20.7	7.2 ± 15.7	0.15
IIEF-5	5.8 ± 5.9	8.9 ± 7.4	<0.001
IPSS	9.5 ± 9.4	7.6 ± 8.1	<0.001
SDS	50.2 ± 11.0	44.2 ± 11.6	<0.001
BMI	22.6 ± 2.7	22.4 ± 2.7	0.12

Figure 1. Comparison of total and sub-scales (mental, physical and sexual scales) of Aging Male Symptom (AMS) scores between Japanese men before and six months after testosterone replacement therapy (TRT) in late-onset hypogonadism (LOH) patients. *Significantly different from value before TRT (p < 0.001).

Figure 2. Comparison of scale scores on the Medical Outcomes Study 8-Item Short-Form Health Survey (SF-8) between Japanese men before and six months after the introduction of testosterone replacement therapy (TRT). PF, physical function; RP, role limitation due to physical problems; BP, bodily pain; GH, general health; VT, vitality; SF, social function; RE, role limitation due to emotional problems and MH, mental health. * and ** significantly different from the value before TRT (p < 0.01 and p < 0.005, respectively).