Anti-diabetic activity of Emblica officinalis in animal models

Figures & data

Table 1.  Effect of varied doses of E. officinalis seed aqueous extract on blood glucose level (BGL) during fasting blood glucose (FBG) test of normoglycemic rats (mean ± SD).

Experimental group	Treatment (mg kg^−1 b.w.)	Blood glucose level (mg/dL)
		Pretreatment FBG	Post-treatment (h)
			0	2	4	6
Control	Distilled water	74.2 ± 3.2	74.1 ± 3.8	73.2 ± 4.2	74.7 ± 3.3	74.1 ± 3.7
Treated 1	100	73.2 ± 3.6	71.7 ± 5.7	63.2 ± 4.6	60.7 ± 3.5	59.8 ± 4.2*
Treated 2	200	72.9 ± 3.9	70.6 ± 4.9	66.3 ± 3.5	60.1 ± 3.8*	59.8 ± 5.1*
Treated 3	300	73.5 ± 4.2	70.1 ± 5.1	62.7 ± 3.7	54.6 ± 4.4*	53.4 ± 4.6*
Treated 4	400	75.8 ± 4.5	72.5 ± 3.2	66.1 ± 4.2	59.7 ± 5.1	58.5 ± 4.3

*p < 0.01 as compared with initial value.

Table 2.  Effect of varied doses of E. officinalis seed aqueous extract on blood glucose level (BGL) during glucose tolerance test (GTT) of normoglycemic rats (mean ± SD).

Experimental group	Treatment (mg kg^−1 b.w.)	Blood glucose level (mg/dL)
		Pretreatment FBG	Post-treatment (h)
			0	1	2	3
Control	Distilled water	73.2 ± 4.5	73.7 ± 4.9	108.9 ± 3.7	103.1 ± 4.5	95.3 ± 4.1
Treated 1	100	74.7 ± 3.7	72.8 ± 4.1	89.4 ± 3.9	82.5 ± 4.4	75.3 ± 3.2*
Treated 2	200	75.1 ± 3.4	72.5 ± 4.4	88.6 ± 5.2	79.9 ± 4.6*	73.4 ± 3.9*
Treated 3	300	76.4 ± 4.2	73.2 ± 3.6	85.1 ± 3.4	78.3 ± 3.5**	71.2 ± 4.6*
Treated 4	400	72.7 ± 4.6	69.6 ± 3.9	86.2 ± 3.1	83.1 ± 4.7**	74.2 ± 4.9

*p < 0.01, **p < 0.001 as compared with control.

Figure 1.  Effect of varied doses of E. officinalis seed aqueous extract on BGL during GTT in sub-diabetic rats. *p < 0.01 as compared with control. Control: distilled water; Treated 1: 100 mg kg⁻¹; Treated 2: 200 mg kg⁻¹; Treated 3: 300 mg kg⁻¹; Treated 4: 400 mg kg⁻¹; Tolbutamide: 250 mg kg⁻¹.

Figure 2.  Effect of varied doses of E. officinalis seed aqueous extract on BGL during GTT in mild-diabetic rats. *p < 0.001 as compared with control. Control: distilled water; Treated 1: 100 mg kg⁻¹; Treated 2: 200 mg kg⁻¹; Treated 3: 300 mg kg⁻¹; Treated 4: 400 mg kg⁻¹; Tolbutamide: 250 mg kg⁻¹.