Evaluation of the antibacterial activity of the methylene chloride extract of Miconia ligustroides, isolated triterpene acids, and ursolic acid derivatives

Figures & data

Figure 1.  Chemical structures of ursolic acid (1), oleanolic acid (2), and ursolic acid derivatives (1a and 1b).

Table 1.  Minimum inhibitory concentration values obtained for methylene chloride extract of M. ligustroides, triterpenes, and ursolic acid derivatives.

	Microorganism
	B. cereus	K. pneumoniae	S. choleraesuis	S. pneumoniae	V. cholerae
Extract	625	>1000	>1000	>1000	>1000
(1)	20	1000	1000	1000	>1000
(1a)	>1000	>1000	>1000	50	>1000
(1b)	>1000	>1000	>1000	50	>1000
(2)	80	1000	1000	80	>1000
(1) + (2)	>1000	1000	1000	>1000	>1000
Positive control	0.18 (v)	2.95 (i)	0.36 (g)	0.18 (v)	0.73 (g)

Minimum inhibitory concentration values are expressed in μg/mL.

Positive control: g, gentamicin; i, imipenem; v, vancomycin.