Nootropic activity of Celastrus paniculatus seed

Figures & data

Table 1.  Effect of C. paniculatus on transfer latency (TL) of rats using elevated plus maze.

Group	Treatment	TL after 24 h (s)	TL on day 30 (s)
1	Control	17.1 ± 2.63	29.1 ± 5.87
2	Piracetam	20.6 ± 3.66	10.2 ± 1.19*
3	CP (350 mg/kg)	24.2 ± 5	18.2 ± 3.43*
4	CP (1050 mg/kg)	25.4 ± 5.41	13 ± 3.08*

CP, Celastrus paniculatus.

Values are mean ± SEM; *p<0.05.

Table 2.  Effect of C. paniculatus on step-down latency (SDL) of cognitive deficit mice using step-down (passive avoidance) apparatus.

Group	Treatment	SDL after 24 h (s)	SDL on day 15 (s)
1	Control (NaNO2 and distilled water)	160.9 ± 38.93	48.25 ± 10.18
2	NaNO2 and Piracetam	157.2 ± 47.75	270 ± 30**
3	NaNO2 and CP (500 mg/kg)	159.6 ± 41.4	243.4 ± 31.72**
4	NaNO2 and CP (1500 mg/kg)	227.4 ± 34.28*	180.8 ± 47.31*

NaNO₂, sodium nitrite.

Values are mean ± SEM. *p<0.05, **p<0.001.

Table 3.  Effect of C. paniculatus on brain acetylcholinesterase activity.

Group	Treatment	Cholinesterase activity (μM/min/g of tissue)	Inhibition of cholinesterase activity (%)
1	Control	39.64 ± 1.89
2	Piracetam	30.05 ± 1.92**	24.2
3	CP (350 mg/kg)	34.42 ± 1.36*	13.17
4	CP (1050 mg/kg)	31.98 ± 1.91**	19.33

Values are mean ± SEM, *p<0.05, **p<0.01.