Hypolipidemic effect of fucoidan from Laminaria japonica in hyperlipidemic rats

Figures & data

Table 1.  Effect of fucoidan polysaccharide sulfuric acid ester (FPS) on serum blood lipids in hyperlipidemic rats.

Group	Dose (g/kg)	TC	TG	HDL-C	LDL-C
Normal		1.72 ± 0.40***	0.89 ± 0.29***	0.46 ± 0.09***	0.85 ± 0.35***
Control		10.27 ± 1.71	4.95 ± 1.62	0.31 ± 0.06	7.71 ± 1.61
GP	0.03	5.65 ± 1.32***	3.42 ± 1.55*	0.40 ± 0.09*	3.70 ± 1.33***
Low-dose FPS	0.1	5.55 ± 1.28***	3.39 ± 1.39*	0.40 ± 0.09*	3.61 ± 1.12***
Moderate-dose FPS	0.2	5.20 ± 0.99***	3.10 ± 1.06**	0.41 ± 0.08**	3.38 ± 1.23***
High-dose FPS	0.4	5.63 ± 1.42***	3.65 ± 1.52	0.37 ± 0.09	3.60 ± 1.18***

Values are mean ± SEM (n = 10). *p < 0.05; **p < 0.01; ***p < 0.001 vs. control value. GP, Gynostemma pentaphyllum.

Table 2.  Effect of FPS on serum LPL, HL, and LCAT activities in hyperlipidemic rats.

Group	Dose (g/kg)	LPL (μmol/mL)	HL (μmol/mL)	LCAT (nmol/mL)
Normal		31.56 ± 4.21***	11.47 ± 1.58***	36.62 ± 4.09***
Control		13.32 ± 1.46	7.96 ± 1.03	20.16 ± 4.13
GP	0.03	18.66 ± 2.71**	9.62 ± 1.34**	25.78 ± 4.15**
Low-dose FPS	0.1	17.98 ± 2.83*	9.88 ± 1.46*	24.59 ± 3.80*
Moderate-dose FPS	0.2	19.41 ± 2.79**	10.16 ± 1.59**	25.42 ± 3.62**
High-dose FPS	0.4	16.05 ± 2.45	8.33 ± 1.21	23.72 ± 3.53

Values are mean ± SEM (n = 10). *p < 0.05; **p < 0.01; ***p < 0.001 vs. control value.