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Research Article

Hepatoprotective activities of two Ethiopian medicinal plants

Shemsu UmerDepartment of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Kaleab AsresDepartment of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, EthiopiaCorrespondence[email protected]

Ciddi VeereshamDepartment of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia

Figures & data

Table 1. Effects of the hydro-alcoholic extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

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Table 2. Effects of the different Soxhlet extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

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Table 3. Effects of fractions from the solid phase extraction of the methanol extract of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

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Table 4. Effects of the methanol extracts of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil. (25 µL/kg), i.p.

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Figure 1. Representative microphotographs of H&E (×10)-stained histological sections of liver (1A) CCl₄ control; (1B) mice treated with fraction A₀ (distilled water fraction of Justicia schimperiana), 50 mg/ kg, p.o. and CCl₄ (25 µL/kg, i.p.); (1C) vehicle control; (1D) mice treated with A₀, 100 mg/kg and CCl₄ (25 µL/kg, i.p.); (1E) mice treated with silymarin 50 mg/kg, p.o. and CCl₄ (25 µL/kg, i.p.); (1F) mice treated with A₁ (25% methanol fraction of Justicia schimperiana), 50 mg/kg and CCl₄ (25 µL/kg, i.p.); (1G) mice treated with fraction A₄ (pure methanol fraction of Justicia schimperiana) 50 mg/kg, p.o. and CCl₄ (25 µL/kg, i.p.).

$Figure 1. Representative microphotographs of H&E (×10)-stained histological sections of liver (1A) CCl4 control; (1B) mice treated with fraction A0 (distilled water fraction of Justicia schimperiana), 50 mg/ kg, p.o. and CCl4 (25 µL/kg, i.p.); (1C) vehicle control; (1D) mice treated with A0, 100 mg/kg and CCl4 (25 µL/kg, i.p.); (1E) mice treated with silymarin 50 mg/kg, p.o. and CCl4 (25 µL/kg, i.p.); (1F) mice treated with A1 (25% methanol fraction of Justicia schimperiana), 50 mg/kg and CCl4 (25 µL/kg, i.p.); (1G) mice treated with fraction A4 (pure methanol fraction of Justicia schimperiana) 50 mg/kg, p.o. and CCl4 (25 µL/kg, i.p.).$

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Hepatoprotective activities of two Ethiopian medicinal plants

Table 1. Effects of the hydro-alcoholic extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 2. Effects of the different Soxhlet extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 3. Effects of fractions from the solid phase extraction of the methanol extract of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 4. Effects of the methanol extracts of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil. (25 µL/kg), i.p.

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Hepatoprotective activities of two Ethiopian medicinal plants

Figures & data

Table 1. Effects of the hydro-alcoholic extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl4 in olive oil (25 µL/kg), i.p.

Table 2. Effects of the different Soxhlet extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl4 in olive oil (25 µL/kg), i.p.

Table 3. Effects of fractions from the solid phase extraction of the methanol extract of Justicia schimperiana on activities of serum enzymes in mice injected with CCl4 in olive oil (25 µL/kg), i.p.

Table 4. Effects of the methanol extracts of Justicia schimperiana on activities of serum enzymes in mice injected with CCl4 in olive oil. (25 µL/kg), i.p.

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Table 1. Effects of the hydro-alcoholic extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 2. Effects of the different Soxhlet extracts of Justicia schimperiana and Verbascum sinaiticum at a dose of 200 mg/kg on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 3. Effects of fractions from the solid phase extraction of the methanol extract of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil (25 µL/kg), i.p.

Table 4. Effects of the methanol extracts of Justicia schimperiana on activities of serum enzymes in mice injected with CCl₄ in olive oil. (25 µL/kg), i.p.