Effect of myricetin on blood pressure and metabolic alterations in fructose hypertensive rats

Figures & data

Figure 1.  Effect of myricetin on systolic blood pressure (S.B.P.) in rats. n = 5 rats per group. Data are expressed as mean ± SEM. *p < 0.05 when compared to control and ^†p < 0.05 when compared to fructose-treated group. F, fructose; M, myricetin.

Figure 2.  Mean change in blood pressure (B.P.) with various drugs: adrenaline (Adr, 1 µg/kg), noradrenaline (NA, 1 µg/kg), phenylephrine (PE, 1 µg/kg), and angiotensin II (Ang II, 25 ng/kg) in rats. Data are expressed as mean ± SEM. *p < 0.05 when compared to control and ^†p < 0.05 when compared to fructose-treated group. F, fructose; M, myricetin.

Table 1.  Effect of myricetin on gain in body weight, heart rate, and serum concentrations of glucose, cholesterol, triglycerides, and insulin in fructose hypertensive rats.

	Control	M (100 mg/kg)	M (300 mg/kg)	Fructose (10%)	Fructose + M (100 mg/kg)	Fructose + M (300 mg/kg)
Gain in body weight (g)	50.00 ± 5.86	68.00 ± 8.02	49.33 ± 4.84	66.67 ± 5.67	76.00 ± 4.36	45.00 ± 3.06
Heart rate (beats/min)	358 ± 8.74	360.7 ± 1.45	356 ± 3.22	364.3 ± 3.48	363 ± 3.61	357.7 ± 5.78
Glucose (mmol/L)	8.22 ± 0.53^†	8.18 ± 0.19^†	8.05 ± 0.1424^†	13.82 ± 0.53^*	10.91 ± 0.23^*†	10.16 ± 0.44^*†
Cholesterol (mmol/L)	1.43 ± 0.04^†	1.38 ± 0.07^†	1.47 ± 0.09^†	3.49 ± 0.21^*	2.25 ± 0.12^*†	2.26 ± 0.07^*†
Triglycerides (mmol/L)	1.52 ± 0.06^†	1.55 ± 0.02^†	1.60 ± 0.061^†	6.33 ± 0.33^*	5.84 ± 0.12^*	2.80 ± 0.31^*†
Insulin (pmol/L)	54.22 ± 2.55^†	49.08 ± 3.50^†	33.33 ± 1.84^*†	83.80 ± 1.01^*	76.63 ± 1.23^*	65.98 ± 2.12^*†
Insulin resistance index (HOMA)	2.86 ± 0.29^†	2.56 ± 0.16^†	1.72 ± 0.12^*†	7.44 ± 0.18^*	5.35 ± 0.44^*†	4.47 ± 0.34^*†

Note. Results are expressed as mean ± SEM for five animals per group. *p < 0.05 when compared to control and ^†p < 0.05 when compared to fructose-treated group. M, myricetin; HOMA, homeostasis model assessment.

Figure 3.  Effect of myricetin on the cumulative concentration–response curve (CCRC) of angiotensin II on isolated rat ascending colon in rats. n = 5 rats per group. Data are expressed as mean ± SEM. *p < 0.05 when compared to control and ^†p < 0.05 when compared to fructose-treated group. F, fructose; M, myricetin.