Protective effect of Matricaria chamomilla on ethanol-induced acute gastric mucosal injury in rats

Figures & data

Table 1.  Effects of hydroalcoholic extract obtained from aerial parts of Matricaria chamomilla L. (MCE, 25–400 mg/kg) and famotidine (FAM, 20 mg/kg) on ethanol (80%)-induced gastric mucosal injury in rats.

Group	n	Ulcer index (%) (mean ± SD)	Inhibition (%)
Control (ethanol)	7	20.67 ± 1.6	—
MCE-25 + ethanol	7	18.79 ± 2.8	9.1
MCE-50 + ethanol	7	11.87 ± 1.2**	42.6
MCE-100 + ethanol	7	15.96 ± 1.7*	22.8
MCE-200 + ethanol	7	8.61 ± 2.7**	58.3
MCE-400 + ethanol	7	10.29 ± 2.7**	50.2
FAM + ethanol	7	6.08 ± 1.8**	70.6
Intact	7	0	—
MCE-100	7	0	—

Note. *p < 0.01, **p < 0.001, vs. control.

Figure 1.  Effects of 25–400 mg/kg doses of hydroalcoholic extract obtained from aerial parts of Matricaria chamomilla L. (MCE, 25–400 mg/kg) and famotidine (FAM, 20 mg/kg) on gastric tissue MDA levels in experimental groups. n = 7, *p < 0.01, **p < 0.001, vs. control.

Figure 2.  Effects of 25–400 mg/kg doses of hydroalcoholic extract obtained from aerial parts of Matricaria chamomilla L. (MCE, 25–400 mg/kg) and famotidine (FAM, 20 mg/kg) on gastric tissue GSH levels in experimental groups. n = 7, *p < 0.05, **p < 0.01, ***p < 0.001, vs. control.

Table 2.  Effects of hydroalcoholic extract obtained from aerials part of Matricaria chamomilla L. (MCE, 25–400 mg/kg) and famotidine (FAM, 20 mg/kg) on whole blood MDA and GSH levels (mean ± SD) in rats.

Group	n	MDA (nmol/mg tissue)	GSH (nmol/g tissue)
Control (ethanol)	7	4.16 ± 0.8	39.09 ± 5.8
MCE-25 + ethanol	7	3.55 ± 0.3	40.32 ± 4.1
MCE-50 + ethanol	7	2.42 ± 0.4***	48.65 ± 3.3**
MCE-100 + ethanol	7	3.48 ± 0.3	46.72 ± 4.4*
MCE-200 + ethanol	7	3.65 ± 0.7	45.48 ± 4.3
MCE-400 + ethanol	7	3.64 ± 0.6	49.39 ± 3.1**
FAM + ethanol	7	2.66 ± 0.7**	44.03 ± 3.9
Intact	7	1.94 ± 0.2***	46.00 ± 1.6
MCE-100	7	1.99 ± 0.8***	45.63 ± 1.5

Note. *p < 0.05, **p < 0.01, ***p < 0.001, vs. control.

Table 3.  Effects of hydroalcoholic extract obtained from aerial parts of Matricaria chamomilla L. (MCE, 25–400 mg/kg) and famotidine (FAM, 20 mg/kg) on serum antioxidant vitamin levels (mean ± SD) in rats.

Group	n	Ascorbic acid (mg/dL)	Retinol (μg/dL)	β-Carotene (μg/dL)
Control (ethanol)	7	2.15 ± 0.6	56.14 ± 3.6	25.19 ± 1.8
MCE-25 + ethanol	7	2.03 ± 0.5	58.36 ± 3.2	26.26 ± 2.1
MCE-50 + ethanol	7	2.58 ± 0.6	62.64 ± 3.3	29.53 ± 2.0
MCE-100 + ethanol	7	2.48 ± 0.5	58.56 ± 3.6	28.88 ± 2.2
MCE-200 + ethanol	7	2.31 ± 0.3	64.17 ± 3.8*	31.14 ± 2.9*
MCE-400 + ethanol	7	2.41 ± 0.6	61.45 ± 2.8	29.77 ± 2.6
FAM + ethanol	7	1.51 ± 0.7	56.73 ± 4.4	27.66 ± 2.6
Intact	7	2.56 ± 0.3	64.69 ± 3.8*	28.21 ± 2.5
MCE-100	7	2.51 ± 0.5	69.78 ± 8.8*	28.60 ± 2.5

Note. *p < 0.01, vs. control.