Neuropharmacological activity of hydroalcoholic extract of leaves of Colocasia esculenta

Figures & data

Table 1.  Effect of hydroalcoholic extract of C. esculenta leaves in the elevated plus maze test^a.

Treatment	Dose (mg/kg, p.o.)	Time spent (seconds)		No. of entries
		Open arm	Close arm	Open arm	Close arm
Control	–	6.0 ± 6.076	296.0 ± 6.076	0.6 ± 0.26	7.2 ± 0.8
Diazepam	5^b	162.6 ± 23.86^***	167.6 ± 23.86^***	7.0 ± 0.63^***	2.6 ± 0.61^***
HECE	100	82.2 ± 16.91^**	217.80 ± 16.91^**	6.2 ± 0.68^**	6.0 ± 0.31^**
HECE	200	98.60 ± 10.1^**	201.60 ± 10.1^**	6.0 ± 1.61^**	6.0 ± 0.66^*
HECE	400	119.6 ± 16.27^***	180.6 ± 16.27^***	6.0 ± 0.83^**	2.8 ± 0.66^***

^aValues are expressed as mean ± SEM (n = 5); ^bintraperitoneal route; ^*p < 0.05, ^**p < 0.01, ^***p < 0.001; compared with control (one-way ANOVA followed by Student-Newman-Keuls test).

Table 2.  Effect of hydroalcoholic extract of C. esculenta leaves on the immobility period during behavior despair test^a.

Treatment	Dose (mg/kg, p.o.)	Immobility period (seconds)
Control	-	166.0 ± 17.266
Imipramine	12.5^b	80.6 ± 17.166^**
HECE	100	67.00 ± 16.990^**
HECE	200	78.60 ± 9.168^**
HECE	400	88.60 ± 7.160^**

^aValues are expressed as mean ± SEM (n = 5); ^bintraperitoneal route; ^**p < 0.01, compared with control (one-way ANOVA followed by Student-Newman-Keuls test).

Figure 1.  Effect of C. esculenta extract on thiopental-induced sleeping time in mice (sleeping time plotted as mean ± SEM). ^*p < 0.05, ^***p < 0.001.

Table 3.  Effect of hydroalcoholic extract of C. esculenta leaves on muscle relaxant activity in rotarod performance^a.

Treatment	Dose (mg/kg, i.p.)	Time of permanence (seconds)
Control	–	306.2 ± 14.551
Diazepam	0.5	36.60 ± 5.105^***
HECE	50	112.2 ± 22.085^***
HECE	100	90.00 ± 23.900^***

^aValues are expressed as mean ± SEM (n = 5). ^***p < 0.001, compared with control (one-way ANOVA followed by Student-Newman-Keuls test).