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Research Article

Pharmacological basis for the medicinal use of Holarrhena antidysenterica in gut motility disorders

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Pages 1240-1246 | Received 08 Nov 2009, Accepted 24 Feb 2010, Published online: 07 Sep 2010

Figures & data

Figure 1. Bar diagram showing the spasmogenic effect of the crude extract of Holarrhena antidysenterica (HaCE) on isolated guinea pig ileum preparations in the absence and presence of pyrilamine. Values shown are mean ± SEM, from three to six determinations.

Figure 1.  Bar diagram showing the spasmogenic effect of the crude extract of Holarrhena antidysenterica (HaCE) on isolated guinea pig ileum preparations in the absence and presence of pyrilamine. Values shown are mean ± SEM, from three to six determinations.

Figure 2. Concentration-response curves of the crude extract of Holarrhena antidysenterica (HaCE) on spontaneous contractions of isolated rabbit jejunum in the absence and presence of pyrilamine (0.1 μM) as well as on K+-induced contractions in jejunum preparations. Values shown are mean ± SEM, from four to seven determinations.

Figure 2.  Concentration-response curves of the crude extract of Holarrhena antidysenterica (HaCE) on spontaneous contractions of isolated rabbit jejunum in the absence and presence of pyrilamine (0.1 μM) as well as on K+-induced contractions in jejunum preparations. Values shown are mean ± SEM, from four to seven determinations.

Figure 3. Concentration-response curves of Ca++ in the absence and presence of increasing concentrations of (A) crude extract of Holarrhena antidysenterica (HaCE) and (B) verapamil in isolated rabbit jejunum preparations. Values shown are mean ± SEM, from five to six determinations.

Figure 3.  Concentration-response curves of Ca++ in the absence and presence of increasing concentrations of (A) crude extract of Holarrhena antidysenterica (HaCE) and (B) verapamil in isolated rabbit jejunum preparations. Values shown are mean ± SEM, from five to six determinations.

Figure 4. Bar diagram showing the concentration-dependent spasmogenic effect of the aqueous fraction (HaAq) of Holarrhena antidysenterica on isolated guinea pig ileum preparations. Values shown are mean ± SEM, from four determinations.

Figure 4.  Bar diagram showing the concentration-dependent spasmogenic effect of the aqueous fraction (HaAq) of Holarrhena antidysenterica on isolated guinea pig ileum preparations. Values shown are mean ± SEM, from four determinations.

Figure 5. Concentration-response curves of aqueous fraction of Holarrhena antidysenterica (HaAq) on spontaneous contractions of isolated rabbit jejunum in the absence and presence of pyrilamine (0.1 μM) as well as on K+-induced contractions in jejunum preparations. Values shown are mean ± SEM, from three to four determinations.

Figure 5.  Concentration-response curves of aqueous fraction of Holarrhena antidysenterica (HaAq) on spontaneous contractions of isolated rabbit jejunum in the absence and presence of pyrilamine (0.1 μM) as well as on K+-induced contractions in jejunum preparations. Values shown are mean ± SEM, from three to four determinations.

Figure 6. Concentration-response curves of n-butanol fraction of Holarrhena antidysenterica (HaB) on spontaneous contractions of isolated rabbit jejunum and on K+-induced contractions in rabbit jejunum preparations. Values shown are mean ± SEM, from four to six determinations.

Figure 6.  Concentration-response curves of n-butanol fraction of Holarrhena antidysenterica (HaB) on spontaneous contractions of isolated rabbit jejunum and on K+-induced contractions in rabbit jejunum preparations. Values shown are mean ± SEM, from four to six determinations.

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