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Research Article

Toxicological studies on aqueous extract of Gmelina arborea in rodents

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Pages 1413-1420 | Received 30 Nov 2009, Accepted 24 Apr 2010, Published online: 26 Aug 2010

Figures & data

Table 1. Sign of toxicity, mortality results of acute toxicity study of Gmelina arborea extract in mice.

Figure 1. Effect of aqueous extract of Gmelina arborea (AE) on body weight changes in mice. Each point represents mean ± SEM (n = 3).

Figure 1.  Effect of aqueous extract of Gmelina arborea (AE) on body weight changes in mice. Each point represents mean ± SEM (n = 3).

Figure 2. Effect of aqueous extract of Gmelina arborea (AE) on food (A) and water (B) intake in mice. Each point represents mean ± SEM (n = 3).

Figure 2.  Effect of aqueous extract of Gmelina arborea (AE) on food (A) and water (B) intake in mice. Each point represents mean ± SEM (n = 3).

Figure 3. Effect of aqueous extract of Gmelina arborea (AE) on body weight changes in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Figure 3.  Effect of aqueous extract of Gmelina arborea (AE) on body weight changes in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Figure 4. Effect of aqueous extract of Gmelina arborea (AE) on food intake in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Figure 4.  Effect of aqueous extract of Gmelina arborea (AE) on food intake in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Figure 5. Effect of aqueous extract of Gmelina arborea (AE) on water intake in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Figure 5.  Effect of aqueous extract of Gmelina arborea (AE) on water intake in male rats (A) and female rats (B). Data are expressed as mean ± SEM (n = 5).

Table 2. Effect of aqueous extract of Gmelina arborea (AE) on hematological values in repeated dose toxicity.

Table 3. Effect of aqueous extract of Gmelina arborea (AE) on blood chemistry values in repeated dose toxicity.

Table 4. Effect of aqueous extract of Gmelina arborea (AE) on organ weights (g) in rats in repeated dose toxicity.

Figure 6. Histopathological analysis (400×) of organs treated with aqueous extract AE (repeated dose toxicity study): (A) liver from control group; (B) liver from AE 2000 mg/kg/bw treated group; (C) kidney from control group; (D) kidney from AE 2000 mg/kg/bw treated group; (E) intestine from control; (F) intestine from AE 2000 mg/kg/bw treated group.

Figure 6.  Histopathological analysis (400×) of organs treated with aqueous extract AE (repeated dose toxicity study): (A) liver from control group; (B) liver from AE 2000 mg/kg/bw treated group; (C) kidney from control group; (D) kidney from AE 2000 mg/kg/bw treated group; (E) intestine from control; (F) intestine from AE 2000 mg/kg/bw treated group.

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