Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats

Figures & data

Table 1.  Effect of hydroalcoholic extract of T. chebula on ulcer index score against aspirin-, ethanol- and cold restraint stress-induced gastric ulcer in rats.

Treatment	Dose(mg/kg p.o.)	Ulcer index score
		Aspirin	Ethanol	Cold restraint stress
Vehicle control	1 mL/100g	47.33 ± 0.94	26.67 ± 3.07	44.91 ± 4.78
T. chebula extract	200	11.42 ± 1.45**	17.08 ± 2.31**	15.83 ± 2.74**
T. chebula extract	500	7.08 ± 1.72**	10.83 ± 0.87**	9.25 ± 1.64**
Omeprazol	20	6.42 ± 1.45**	6.58 ± 1.1**	7.58 ± 1.89**

Results are mean ± SEM (n = 6). Statistical comparison was performed using ANOVA followed by Dunnett’s t-test.*p < 0.05, **p < 0.01, were consider statistically significant compared with control group.

Table 2.  Effect of hydroalcoholic extract of T. chebula on mucus content against aspirin- and ethanol-induced gastric ulcer in rats.

Treatment	Dose(mg/kg, p.o.)	Mucus content(μg/g wet tissue)
		Aspirin	Ethanol
Vehicle control	1 ml/100g	0.34 ± 0.01	0.49 ± 0.02
T. chebula extract	200	0.56 ± 0.03**	0.77 ± 0.04**
T. chebula extract	500	0.64 ± 0.02*	0.84 ± 0.03**
Omeprazol	20	0.66 ± 0.02**	0.89 ± 0.02**

Results are mean ± SEM (n = 6). Statistical comparison was performed using ANOVA followed by Dunnett’s t-test.*p < 0.05, **p < 0.01 were consider statistically significant compared with control group.

Table 3.  Effect of hydroalcoholic extract of T. chebula on gastric secretion, acidity, pH and ulcer score in pylorus-ligated rats.

Treatment (mg/kg)	Volume of gastric secretion (mL/100 g)	Free acidity(mEq./L/100 g)	Total acidity(mEq./L/100 g)	pH	Ulcer score
Vehicle control(1 mL/100 g)	5.0 ± 0.36	4.23 ± 0.03	17.9 ± 0.10	1.42 ± 0.07	48.33 ± 4.55
T. chebula extract(200 mg/kg)	4.12 ± 0.08**	3.35 ± 0.09	9.40 ± 0.13	2.38 ± 0.15	13.42 ± 1.98**
T. chebula extract(500 mg/kg)	3.5 ± 0.18**	3.21 ± 0.06	8.08 ± 0.03	3.20 ± 0.06	11.42 ± 1.72**
Omeprazol(20 mg/kg)	2.98 ± 0.12**	2.93 ± 0.05	7.23 ± 0.14	4.61 ± 0.15	10.83 ± 0.87**

Results are mean ± SEM (n = 6). Statistical comparison was performed by using ANOVA followed by Dunnett’s t-test.*p < 0.05, **p < 0.01 were consider statistically significant compared with control group.

Figure 1.  Effect of hydroalcoholic extract of T. chebula on percentage protection of ulcer index in different ulcer models. Results are mean ± SEM (n = 6). Statistical comparison was performed by using ANOVA followed by Dunnett’s t-test.*p < 0.05, **p < 0.01were consider statistically significant compared with control group.