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Research Article

Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

David E. WilliamsDepartments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada,

Frank LoganzoCenter for Integrative Biology and Biotherapeutics, Pfizer, Pearl River, New York, USA,

Lauren WhitneyCenter for Integrative Biology and Biotherapeutics, Pfizer, Pearl River, New York, USA,

Jenny TogiasScreening Sciences, Wyeth Research, Collegeville, Pennsylvania, USA,

Richard HarrisonScreening Sciences, Wyeth Research, Collegeville, Pennsylvania, USA,

Maya P. SinghNatural Products, Pfizer, Pearl River, New York, USA

Leonard A. McDonaldNatural Products, Pfizer, Pearl River, New York, USA

Selvaluxmy KathirgamanatharDepartment of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka

Veranja KarunaratneDepartment of Chemistry, University of Peradeniya, Peradeniya, Sri Lanka

Raymond J. AndersenDepartments of Chemistry and Earth & Ocean Sciences, University of British Columbia, Vancouver, British Columbia, Canada,Correspondence[email protected]

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Figures & data

Figure 1. The structures of depsides 1–3.

Table 1. Comparison of the ¹H and ¹³C NMR data for depsides 1 and 2 recorded at 600 MHz in acetone-d₆.

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Table 2. Inhibition of recombinant Plk1 kinase by depsides 1–3 and reference compounds.

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Table 3. ATP dependence of depsides 1–3 and reference compounds.

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Table 4. Kinase selectivity profile of depsides 1–3.

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Figure 2. gCOSY connectivities (in bold) and key gHMBC (arrow) correlations used to assign the structure of depside 1.

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Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

Table 1. Comparison of the ¹H and ¹³C NMR data for depsides 1 and 2 recorded at 600 MHz in acetone-d₆.

Table 2. Inhibition of recombinant Plk1 kinase by depsides 1–3 and reference compounds.

Table 3. ATP dependence of depsides 1–3 and reference compounds.

Table 4. Kinase selectivity profile of depsides 1–3.

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Depsides isolated from the Sri Lankan lichen Parmotrema sp. exhibit selective Plk1 inhibitory activity

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Table 1. Comparison of the 1H and 13C NMR data for depsides 1 and 2 recorded at 600 MHz in acetone-d6.

Table 2. Inhibition of recombinant Plk1 kinase by depsides 1–3 and reference compounds.

Table 3. ATP dependence of depsides 1–3 and reference compounds.

Table 4. Kinase selectivity profile of depsides 1–3.

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Table 1. Comparison of the ¹H and ¹³C NMR data for depsides 1 and 2 recorded at 600 MHz in acetone-d₆.