Hypoglycemic activity of Erythrina variegata leaf in streptozotocin-induced diabetic rats

Figures & data

Table 1.  Effect of methanol extract of Erythrina variegata leaf (MEEV) on oral glucose tolerance in normal rats.

Time (min)	Blood glucose level (mg/dl)
	Control glucose (4 g/kg)	MEEV 300 mg/kg + glucose (4 g/kg)	MEEV 600 mg/kg + glucose (4 g/kg)	MEEV 900 mg/kg + glucose (4 g/kg)	Glibenclamide (1 mg/kg) + glucose (4 g/kg)
0	85.83 ± 3.60	77.52 ± 4.25	91.33 ± 1.17	88.16 ± 2.53	78.16 ± 5.01
30	135.65 ± 3.94	132.16 ± 2.27	117.16 ± 2.28**	103.83 ± 1.91**	80.05 ± 3.31**
60	121.79 ± 4.42	114.50 ± 3.38*	102.13 ± 3.12**	91.50 ± 1.33**	70.50 ± 2.93**
120	115.66 ± 2.89	101.31 ± 3.05**	95.27 ± 1.43**	84.91 ± 2.56**	68.29 ± 4.05**

Values are mean ± SEM (n = 6).

*P < 0.05, **P < 0.01 when compared with control group at corresponding time.

Table 2.  Effect of methanol extract of Erythrina variegata leaf (MEEV) on fasting blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats.

Treatment	Fasting blood sugar level (mg/dl)
	0 day	7th day	14th day	21st day
Normal control	82.43 ± 4.30**	86.66 ± 4.37**	81.39 ± 5.28**	83.20 ± 6.69**
NC + MEEV 600 mg/kg	95.16 ± 5.12**	85.50 ± 5.10**	80.60 ± 5.62**	76.61 ± 5.00**
STZ control (55 mg/kg)	367.80 ± 8.36^¶	535.50 ± 21.26^¶	438.76 ± 25.29^¶	310.87 ± 22.94^¶
STZ + MEEV 300 mg/kg	312.23 ± 22.84^¶	280.49 ± 19.69**^¶	176.77 ± 16.66**^¶	117.16 ± 9.38**
STZ + MEEV 600 mg/kg	425.16 ± 22.36^¶	284.65 ± 20.29**^¶	165.66 ± 15.63**^¶	99.36 ± 9.60**
STZ + MEEV 900 mg/kg	428.66 ± 22.75^¶	199.35 ± 18.20**^¶	103.28 ± 8.55**	62.53 ± 3.10**
STZ + Glibenclamide 1 mg/kg	378.18 ± 16.12^¶	175.95 ± 11.36**^¶	70.90 ± 4.94**	55.15 ± 3.73**

Values are mean ± SEM (n = 6).

**P < 0.01 when compared with STZ control group; ^¶P < 0.01 when compared with normal control group.

Table 3.  Effect of methanol extract of Erythrina variegata leaf (MEEV) on body weight in normal and streptozotocin (STZ)-induced diabetic rats.

Treatment	Body weight (g)
	0 day	7th day	14th day	21st day
Normal control	165.16 ± 1.66	178.66 ± 3.57**	188.00 ± 2.30**	195.17 ± 2.98**
NC + MEEV 600 mg/kg	157.83 ± 2.89	181.00 ± 2.85**	191.83 ± 1.30**	198.16 ± 2.54**
STZ control (55 mg/kg)	162.33 ± 1.77	152.50 ± 1.68^¶	139.87 ± 2.08^¶	123.00 ± 1.71^¶
STZ + MEEV 300 mg/kg	154.82 ± 3.15	162.16 ± 1.40^§	169.12 ± 2.67**^§	181.33 ± 1.94**^¶
STZ + MEEV 600 mg/kg	161.87 ± 2.90	169.33 ± 1.87**	178.16 ± 2.15**	188.71 ± 2.67**
STZ + MEEV 900 mg/kg	159.28 ± 3.20	171.29 ± 1.85**	182.27 ± 1.56**	193.56 ± 2.58**
STZ + Glibenclamide 1 mg/kg	162.50 ± 3.01	177.50 ± 61**	185.61 ± 2.78**	194.16 ± 1.13**

Values are mean ± SEM (n = 6).

**P < 0.01 when compared with STZ control group; ^§P < 0.05 and ^¶P < 0.01 when compared with normal control group.

Table 4.  Effect of methanol extract of Erythrina variegata leaf (MEEV) on serum biochemical parameters in normal and streptozotocin (STZ)-induced diabetic rats.

Treatment	Glycosylated hemoglobin (% total Hb)	Triglycerides (mg/dl)	Total cholesterol (mg/dl)	HDL cholesterol (mg/dl)	LDL cholesterol (mg/dl)	AST (U/L)	ALT (U/L)	ALP (U/L)
Normal control	5.42 ± 0.29**	51.98 ± 2.83**	76.49 ± 2.86**	30.92 ± 1.65**	36.32 ± 2.40**	55.54 ± 2.36**	26.75 ± 1.57**	53.53 ± 2.33**
NC + MEEV 600 mg/kg	4.75 ± 0.12**	42.36 ± 1.29**	71.6 ± 3.72**	33.98 ± 1.39**	30.29 ± 1.77**	51.31 ± 1.88**	23.53 ± 1.23**	57.63 ± 2.06**
STZ control (55 mg/kg)	12.34 ± 0.47^¶	97.22 ± 3.18^¶	180.17 ± 3.81^¶	19.85 ± 1.04^¶	140.91 ± 2.02^¶	88.81 ± 2.26^¶	63.24 ± 2.56^¶	87.63 ± 2.64^¶
STZ + MEEV 300 mg/kg	10.96 ± 0.49*^¶	88.07 ± 2.57^¶	122.06 ± 4.37**^¶	24.21 ± 2.11	80.79 ± 1.77**^¶	81.46 ± 1.95^¶	52.44 ± 1.94**^¶	81.87 ± 1.09^¶
STZ + MEEV 600 mg/kg	7.66 ± 0.35**^¶	65.15 ± 4.03**^¶	106.59 ± 3.51**^¶	28.48 ± 2.14*	66.20 ± 2.07**^¶	68.63 ± 2.32**^¶	44.20 ± 1.88**^¶	73.07 ± 1.74**^¶
STZ + MEEV 900 mg/kg	5.77 ± 0.42**	50.72 ± 1.55**	92.94 ± 3.06**	31.33 ± 2.46**	50.74 ± 2.80**^¶	58.09 ± 2.75**	32.03 ± 2.25**	65.48 ± 2.23**^¶
STZ + Glibenclamide 1 mg/kg	4.42 ± 0.17**	40.95 ± 1.33**^§	87.48 ± 2.45**	32.14 ± 2.95**	47.82 ± 2.77**^¶	60.12 ± 2.33**	29.27 ± 1.73**	63.38 ± 1.44**^¶

Values are mean ± SEM (n = 6).

*P < 0.05 and **P < 0.01 when compared with STZ control group; ^§P < 0.05 and ^¶P < 0.01 when compared with normal control group.