α-Terpineol reduces nociceptive behavior in mice

Figures & data

Table 1.  Effect of α-terpineol (TPN) or aspirin on writhing induced by acetic acid and formalin-induced nociception tests.

Treatment	Dose (mg/kg)	Writhing test	Formalin test
		Number of writhings^a	0–5 min^a	15–30 min^a
Vehicle	—	15.2 ± 3.0	100.5 ± 9.7	126.3 ± 30.1
TPN	25	4.5 ± 1.3^b	46.0 ± 9.2^b	17.3 ± 8.9^b
TPN	50	1.5 ± 0.7^b	49.1 ± 4.9^b	0.4 ± 0.3^b
TPN	100	0.7 ± 0.4^b	40.5 ± 6.2^b	14.1 ± 10.3^b
Aspirin	200	1.9 ± 1.4^b	83.7 ± 28.9	3.4 ± 2.8^b

n = 8 per group.

^aValues represent mean ± SEM.

^bP < 0.001 (one-way ANOVA and Tukey’s test), significantly different from control group.

Table 2.  Effect of α-terpineol (TPN) or morphine (MOR) on glutamate and capsaicin-induced nociception tests.

Treatment	Dose (mg/kg)	Glutamate test^a	Capsaicin test^a
Vehicle	—	58.1 ± 4.5	53.3 ± 0.9
TPN	25	32.5 ± 5.8^b	25.5 ± 4.4^c
TPN	50	32.1 ± 5.2^b	13.2 ± 2.7^c,d
TPN	100	33.0 ± 3.4^b	4.5 ± 1.0^c,e
MOR	5	4.3 ± 2.2c	1.9 ± 1.7^c

n = 8 per group.

^aValues represent mean ± SEM.

^bP < 0.01 (one-way ANOVA and Tukey’s test), significantly different from control group.

^cP < 0.001 (one-way ANOVA and Tukey’s test), significantly different from control group.

^dP < 0.05 (one-way ANOVA and Tukey’s test), significantly different from TPN 25 mg/kg group.

^eP < 0.05 (one-way ANOVA and Tukey’s test), significantly different from TPN 50 mg/kg group.

Table 3.  Antinociceptive effect of α-terpineol (TPN) or morphine (MOR) on the hot plate test.

Treatment	Dose (mg/kg)	Reaction time (licking of the hind paws) (s)^a
		Basal	0.5 h	1 h	1.5 h	2 h
Vehicle	—	7.1 ± 2.8	11.5 ± 1.5	9.0 ± 1.4	6.7 ± 1.3	5.7 ± 0.3
TPN	25	6.7 ± 2.5	8.3 ± 0.9	11.8 ± 1.1	9.0 ± 1.2	8.8 ± 1.3
TPN	50	7.9 ± 3.1	11.8 ± 1.2	12.2 ± 1.6	12.2 ± 1.8	9.3 ± 0.8
TPN	100	8.7 ± 2.7	10.5 ± 1.1	16.2 ± 1.6^b	17.2 ± 2.1^c	16.7 ± 3.2^c
MOR	5	7.3 ± 3.2	23.5 ± 2.3^c	28.1 ± 0.9^c	27.2 ± 3.6^c	25.0 ± 3.8^c

n = 8 per group.

^aValues represent mean ± SEM.

^bP < 0.01 (one-way ANOVA and Tukey’s test), significantly different from control group.

^cP < 0.001 (one-way ANOVA and Tukey’s test), significantly different from control group.