Pharmacokinetic parameters of morroniside in iridoid glycosides of Fructus corni processing based on back-propagation neural network

Figures & data

Figure 1.  Structure of BP network. The arrows indicate the transfer of neuron excitations of information flow. w_ij represents the connection weight between p_i and the ith hidden node, while w_jk denotes the connection weight between the ith hidden node and t_k.

Table 1.  Pharmacokinetic parameters of oral administration iridoid glycosides of Fructus Corni. (mean ± SD, n = 5).

Pharmacokinetic parameters	Oral administration
	20 mg/kg	40 mg/kg	80 mg/kg
Ke (min^−1)	0.0097 ± 0.0015	0.0066 ± 0.0008	0.0074 ± 0.0014
t1/2 (min)	72.6346 ± 11.3283	106.2873 ± 12.2475	95.9570 ± 18.6468
Cmax (mg/L)	0.7642 ± 0.0844	1.3.0000 ± 0.2645	1.4734 ± 0.2782
Tmax (min)	53.0000 ± 9.7467	58.9974 ± 5.4680	58. 7683 ± 10.2643
AUC0–t	109.0716 ± 14.6384	166.0140 ± 30.3033	182.6015 ± 40.2990
AUCt–∞	11.8985 ± 6.1306	23.99332 ± 8.9463	31.92453 ± 10.3409
AUC0–∞	120.9701 ± 15.1934	190.0073 ± 30.8816	204.526 ± 53.4153

Figure 2.  Mean plasma concentration of morroniside after Oral administration iridoid glycosides of Fructus Corni. (A) Oral administration of 20 mg/kg; (B) Oral administration of 40 mg/kg; (C) Oral administration of 80 mg/kg. Each point and bar represent the mean ± SD (n = 5)

Figure 3.  Predicted vs actual PK parameters: (A) t_1/2 (min); (B) C_max (mg/l); (C) T_max (min); (D) AUC_0–t and (E) AUC_0–inf; (F) MSE of neural network model with 11 hidden neurons and 90% training data is 0.092.