Pharmacological evaluation of Potentilla alba L. in mice: adaptogenic and central nervous system effects

Figures & data

Figure 1.  Effect of extracts on the swimming endurance of mice. RR, Rhodiola rosea; PA12, Potentilla alba at 12 mg/kg; PA36, P. alba at 36 mg/kg; and PA72, P. alba at 72 mg/kg. Values with an asterisk are significantly different from those of the control group as assessed by Student’s t-test at P < 0.05.

Table 1.  Effect of extracts on the biochemical parameters of the blood.

Group	Glucose (mmol/L)	Lactate (mmol/L)	Glycogen (mg/g)
Control	7.4 ± 0.5	5.0 ± 0.6	0.45 ± 0.38
RR	9.3 ± 0.8*	4.4 ± 1.0	0.17 ± 0.11
PA12	8.9 ± 0.8*	6.5 ± 1.0	0.17 ± 0.04
PA36	10.4 ± 0.7*	5.4 ± 2.4	1.31 ± 0.50
PA72	8.2 ± 0.8	6.7 ± 2.5	9.00 ± 3.10*

Data are expressed as the mean ± SEM. RR, R. rosea; PA12, P. alba at 12 mg/kg; PA36, P. alba at 36 mg/kg; and PA72, P. alba at 72 mg/kg.

* Values are significantly different from that of the control group as assessed by Student’s t-test at p < 0.05.

Table 2.  Effect of extracts on the behavioral parameters in the light/dark test.

Group	Light time (sec)	Latency time (sec)	Entries
Control	84.8 ± 36.5	43.3 ± 6.9	2.6 ± 1.4
RR	122.7 ± 42.1	30.9 ± 11.1	1.6 ± 0.8
PA12	78.4 ± 23.5	22.0 ± 7.3	3.9 ± 1.1
PA36	82.9 ± 31.8	31.5 ± 16.3	3.3 ± 1.8
PA72	99.2 ± 29.7	25.1 ± 10.0	2.6 ± 1.6

Data are expressed as the mean ± SEM.

RR, R. rosea; PA12, P. alba at 12 mg/kg; PA36, P. alba at 36 mg/kg; and PA72, P. alba at 72 mg/kg.

Table 3  . Effect of extracts on spontaneous locomotor activity and anxiety-related parameters in the open field test.

Group	Number of squares crossed	Head dips	Rearing	Grooming	Central time
Control	25.4 ± 4.6	12.5 ± 1.8	9.9 ± 1.5	5.4 ± 0.8	5.6 ± 2.6
RR	19.1 ± 2.1	10.6 ± 1.9	5.3 ± 1.2*	4.6 ± 1.0	2.2 ± 1.2
PA12	32.1 ± 0.5*	31.4 ± 3.4*	9.0 ± 2.2	2.6 ± 0.7*	5.9 ± 2.3
PA36	25.1 ± 6.5	10.3 ± 2.3	9.8 ± 4.7	2.0 ± 0.5*	3.3 ± 1.9
PA72	26.4 ± 6.4	15.1 ± 3.1	8.0 ± 1.7	1.6 ± 0.6*	2.6 ± 1.6

Data are expressed as the mean ± SEM. RR, R. rosea; PA12, P. alba at 12 mg/kg; PA36, P. alba at 36 mg/kg; and PA72, P. alba at 72 mg/kg.

* Values are significantly different from that of the control group as assessed by Student’s t-test at p < 0.05.