Figures & data
Figure 1. Apparatus used in sulfur dioxide gas-induced cough model. (A) Three-necked round bottom flask, containing 39% NaHSO3 solution, (B) dropping funnel having concentrated H2SO4, (C) gas reservoir, (D) water manometer, and (E) desiccator. The procedure used to produce sulfur dioxide gas is described in the text.
Figure 2. Antitussive effect of s.c. administered butanol fraction of Ballota limbata (BFBl 200 mg/kg) in sulfur dioxide gas-induced cough model in mice. Codeine (10 mg/kg) and dextromethorphan (10 mg/kg) were used as positive control. Each column represents mean ± SEM. Number of coughs was recorded for 5 min for each condition. n = 8 mice in each group. Significant differences from saline control were indicated as *P < 0.01, **P < 0.001 by Student’s t-test.
Figure 3. Antitussive effect of s.c. administered butanol fraction of Ballota limbata (BFBl) 400 mg/kg in mice. Each column represents mean ± SEM. Number of coughs was recorded for 5 min. n = 8 mice in each group. Significant differences from saline control were indicated as *P < 0.01, **P < 0.001 by Student’s t-test.
Figure 4. Antitussive effect of s.c. administered butanol fraction of Ballota limbata (BFBl) 800 mg/kg in mice. Each column represents mean ± SEM. Number of coughs was recorded for 5 min. n = 8 mice in each group. Significant differences from saline control were indicated as *P < 0.001 by Student’s t-test.
Figure 5. Comparison of antitussive efficacy of butanol fraction of Ballota limbata (BFBl 200, 400, and 800 mg/kg), codeine 10 mg/kg, and dextromethorphan 10 mg/kg in mice.
