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Research Article

Hydroalcoholic extract of Emblica officinalis protects against kainic acid-induced status epilepticus in rats: Evidence for an antioxidant, anti-inflammatory, and neuroprotective intervention

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Pages 1128-1136 | Received 16 Dec 2010, Accepted 09 Mar 2011, Published online: 12 Jul 2011

Figures & data

Figure 1.  Effect of 7 days pretreatment with HAEEO on KA-induced seizures in rats. Each value represents the mean ± SEM. for six rats. aP < 0.001 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 1.  Effect of 7 days pretreatment with HAEEO on KA-induced seizures in rats. Each value represents the mean ± SEM. for six rats. aP < 0.001 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 2.  Effect of 7 day pretreatment with HAEEO on levels of TBARS in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 2.  Effect of 7 day pretreatment with HAEEO on levels of TBARS in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 3.  Effect of 7 day pretreatment with HAEEO on levels of glutathione (GSH) in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 3.  Effect of 7 day pretreatment with HAEEO on levels of glutathione (GSH) in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 4.  Effect of 7 day pretreatment with HAEEO on levels of TNF-α in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 4.  Effect of 7 day pretreatment with HAEEO on levels of TNF-α in KA-induced seizures in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 5.  Effect of 7 day pretreatment with HAEEO on KA-induced cognitive impairment in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01, dP < 0.05 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

Figure 5.  Effect of 7 day pretreatment with HAEEO on KA-induced cognitive impairment in rats. Each value represents the mean ± SEM for six rats. aP < 0.001 compared with control, bP < 0.001, cP < 0.01, dP < 0.05 compared with vehicle-treated KA (ANOVA followed by Tukey-Kramer post test). KA represents kainic acid and HAEEO represents hydroalcoholic extract of Emblica officinalis.

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