Novel flavonoids with antioxidant activity from a Chenopodiaceous plant

Figures & data

Figure 1.  Compounds isolated from Atriplex lentiformis.

Table 1.  Antioxidant activity of different extracts and isolated compounds of Atriplex lentiformis (Torm.) S. Wats.

Extracts and isolated compounds	Antioxidant capacity (µmol Trolox equivalent/gram dry weight
Total ethanol	952
Ether	132
Chloroform	192
Ethyl acetate	810
Butanol	840
Compound-1	985
Compound-2	895
Compound-3	532
Compound-4	520
Compound-5	410
Compound-6	572
Compound-7	465

Table 2.  Effect of Atriplex lentiformis (Torm.) S. Wats extracts on liver functions of rats (M ± SE, n = 5).

Group Control	ALT (U/l)				AST (U/l)
	After 5 days	After 15 days	After 30 days	After 45 days	After 5 days	After 15 days	After 30 days	After 45 days
G.1	4.8 ± 0.37	5.6 ± 0.51	6.4 ± 0.60	7.2 ± 0.49	5.2 ± 0.37	7.4 ± 0.40	8.2 ± 0.49	8.4 ± 0.60
G.2	4.8 ± 0.37	6.8 ± 0.49	6.0 ± 0.58	8.0 ± 0.32	5.6 ± 0.40	8.4 ± 0.40	9.8 ± 0.97	8.6 ± 0.51
G.3	4.4 ± 0.24	7.20 ± 0.68	7.2 ± 0.20	6.4 ± 0.24	5.40 ± 0.24	7.2 ± 0.37	6.8 ± 0.66	8.0 ± 0.63
G.4	4.8 ± 0.49	4.8 ± 0.47	7.6 ± 0.24	8.2 ± 0.20	5.8 ± 0.49	8.8 ± 0.66	9.0 ± 0.89	9.4 ± 0.68
G.5	6.6* ± 0.51	4.80 ± 0.42	7.2 ± 0.66	10.2** ± 0.37	9.2*** ± 0.49	9.8* ± 0.80	11.0** ± 0.55	10.2* ± 0.49
G.6	5.40 0.24	9.40** ± 0.40	10.8*** ± 0.37	11.0*** ± 0.32	6.2 ± 0.49	10.4*** ± 0.24	11.0*** ± 0.32	11.8*** ± 0.37

G₂ (diethyl ether group), G₃ (chloroform group), G₄ (ethyl acetate group), G₅ (n-butanol group) and G₆ (total alcoholic extract group).

Significance: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.00.

Table 3.  Effect of Atriplex lentiformis (Torm.) S. Wats, extracts on kidney functions of rats (M ± SE, n = 5).

Group Control	Blood urea (mg/dl)				Creatinine (mg/dl)
	After 5 days	After 15 days	After 30 days	After 45 days	After 5 days	After 15 days	After 30 days	After 45 days
G.1	45.6 ± 1.36	45.0 ± 4.15	73.4 ± 4.33	67.6 ± 3.80	0.82 ± 0.02	0.89 ± 0.04	0.84 ± 0.01	0.85 ± 0.01
G.2	44.0 ± 1.40	52.4 ± 4.25	64.0 ± 3.54	57.0 ± 5.30	0.86 ± 0.02	0.86 ± 0.01	0.88** ± 0.01	0.90 ± 0.03
G.3	45.4 ± 1.44	39.6 ± 1.08	79.8 ± 5.22	73.0 ± 4.58	0.83 ± 0.01	0.94 ± 0.02	0.87** ± 0.00	0.88* ± 0.01
G.4	43.8 ± 2.15	53.2 ± 2.08	79.2 ± 3.64	71.2 ± 4.21	0.85 ± 0.02	0.96 ± 0.02	0.89** ± 0.01	0.87 ± 0.02
G.5	55.2** ± 2.71	54.4* ± 1.94	89.8* ± 3.90	69.6 ± 1.57	0.89** ± 0.00	1.01* ± 0.04	0.95* ± 0.04	1.03*** ± 0.01
G.6	53.2* ± 2.35	62.6** ± 2.29	69.4 ± 1.57	71.8 ± 1.46	0.88 ± 0.02	1.08*** ± 0.02	1.13*** ± 0.04	1.21*** ± 0.02

Significance: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001.

Table 4.  Effect of isolated compounds on liver and kidney functions of rats (M ± SE, n = 5).

Compound	ALT (U/l)	AST (U/l)	B.urea (mg/dl)	Creatinine (mg/dl)
Control	4.8 ± 0.37	5.2 ± 0.37	45.50 ± 1.36	0.82 ± 0.02
Compound 1	5.1 ± 0.22	5.3 ± 0.39	46.00 ± 1.9	0.84 ± 0.02
Compound 2	4.7 ± 0.37	5.2 ± 0.38	43.2 ± 2.4	0.85 ± 0.02